138448-17-6

Upstream product

• 121533-54-8 (4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 530-62-1 1,1'-carbonyldiimidazole 
• 138448-18-7 [R-(R*,S*)]-β-[[(1,1-Dimethylethoxy)carbonyl]-amino]-α-(2-furanyl)cyclohexanepropanol 
• 138448-19-8 (4S-trans)-4-(cyclohexylmethyl)-5-(2-furanyl)-2,2-dimethyl-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester 
• 115766-13-7 (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-N-methoxy-N-methylcyclohexanepropanamide 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 
• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 131316-86-4 (4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-89-1 (4S,5S)-4-Cyclohexylmethyl-5-((E)-2-methoxycarbonyl-3-methyl-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-89-1 (4S,5S)-4-Cyclohexylmethyl-5-((Z)-2-methoxycarbonyl-3-methyl-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-95-9 (4S,5S)-4-Cyclohexylmethyl-5-((S)-2-methoxycarbonyl-3-methyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-93-7 (4S,5S)-4-Cyclohexylmethyl-5-((R)-2-methoxycarbonyl-3-methyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-90-4 (4S,5S)-5-((Z)-2-Butylcarbamoyl-3-methyl-but-1-enyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-92-6 N-Butyl-2-[1-((4S,5S)-4-cyclohexylmethyl-2-oxo-oxazolidin-5-yl)-meth-(Z)-ylidene]-3-methyl-butyramide 
• 124032-42-4 [(S)-2-Cyclohexyl-1-((S)-4-isopropyl-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 124032-36-6 (3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one 
• 123580-22-3 [(S)-2-Cyclohexyl-1-((2S,4R)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 124032-35-5 (2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide 
• 129921-94-4 N-butyl-2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanamide 
• 105852-64-0 (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide 
• 117997-58-7 tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 

Relevant academic research and scientific papers

DIOL SULFONAMIDE AND SULFINYL RENIN INHIBITORS

Compounds of the formula STR1 wherein Z is SO or SO 2 possess renin inhibition activity and are useful in treating hypertension and other diseases where the reduction of the levels of circulating angiotensin II are beneficial.

Synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

A stereoselective synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid-n-butyl amide from Boc-L-phenylalanine is described.