1384717-11-6Relevant articles and documents
Nickel-catalyzed synthesis of stereochemically defined enamides via Bi- and tricomponent coupling reaction
Liu,De Nisi,Cerveri,Monari,Bandini
, p. 5034 - 5037 (2017)
The stereoselective synthesis of (E)-trisubstituted tertiary enamides is documented via site-selective Ni-catalyzed β-arylation of allenamides with boronic acids in high yields (up to 89%). The nucleophilic character of the "organo-Ni" intermediates is further exploited to implement a one-pot tricomponent procedure involving the final allylation of aldehydes (yields up to 93%). Mechanistic insights and efficiency on a gram scale process were also documented.