1384866-65-2

Basic information

• Product Name: (E)-methyl 4-{2-[4-(dimethylamino)but-1-enyl]benzyloxy}-3-iodophenylacetate
• CAS NO: 1384866-65-2
• Molecular Weight: 479.358
• Mol File: 1384866-65-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-methyl 4-{2-[4-(dimethylamino)but-1-enyl]benzyloxy}-3-iodophenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 4-{2-[4-(dimethylamino)but-1-enyl]benzyloxy}-3-iodophenylacetate(1384866-65-2)
• EPA Substance Registry System: (E)-methyl 4-{2-[4-(dimethylamino)but-1-enyl]benzyloxy}-3-iodophenylacetate(1384866-65-2)

Safety Data

• Hazardous Substances Data: 1384866-65-2(Hazardous Substances Data)

Upstream product

• 18355-96-9 (3-dimethylaminopropyl)-triphenylphosphoniumbromide 
• 60633-91-2 2-(bromomethyl)benzaldehyde 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 
• 352469-17-1 methyl 2-(4-hydroxy-3-iodophenyl)acetate 

Relevant articles and documents

Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer

Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.