1384982-53-9

Basic information

• Product Name: (E)-5-(4-(2,2-dimethoxyethoxy)styryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate
• Synonyms: (E)-5-(4-(2,2-dimethoxyethoxy)styryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate
• CAS NO: 1384982-53-9
• Molecular Weight: 645.58
• Mol File: 1384982-53-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-5-(4-(2,2-dimethoxyethoxy)styryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-(4-(2,2-dimethoxyethoxy)styryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate(1384982-53-9)
• EPA Substance Registry System: (E)-5-(4-(2,2-dimethoxyethoxy)styryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate(1384982-53-9)

Safety Data

• Hazardous Substances Data: 1384982-53-9(Hazardous Substances Data)

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 150022-33-6 (5-iodo-2-nitrophenyl)methanol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 52415-00-6 4-iodo-2-methyl-1-nitro-benzene 
• 611-05-2 4-nitro-3-methylaniline 
• 1384982-44-8 (E)-5-(4-(4-bromobutoxy)styryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-43-7 (E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid 
• 1384982-42-6 (E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-41-5 (E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-52-8 (E)-(5-(4-(2,2-dimethoxyethoxy)styryl)-2-nitrophenyl)methanol 
• 305-03-3 chlorambucil 
• 1384982-51-7 1-(2,2-dimethoxyethoxy)-4-vinylbenzene 
• 1384982-50-6 (E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-40-4 (E)-5-(4-ethoxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 

Downstream Products

• 1384982-40-4 (E)-5-(4-ethoxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-50-6 (E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-41-5 (E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-42-6 (E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-43-7 (E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid 
• 1384982-44-8 (E)-5-(4-(4-bromobutoxy)styryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 1384982-46-0 (E)-2-nitro-5-(4-(2-oxoethoxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 305-03-3 chlorambucil 

Relevant articles and documents

Long conjugated 2-nitrobenzyl derivative caged anticancer prodrugs with visible light regulated release: Preparation and functionalizations

A series of anticancer prodrugs with different chemical functional groups were prepared, in which the styryl conjugated 2-nitrobenzyl derivatives were introduced as the phototrigger to regulate the drug (chlorambucil) release. Compared to the common 4,5-dimethoxy-2-nitrobenzyl caged compounds, most of the prodrugs exhibited large and redshifted one-photon absorption within the visible range. One-photon excitation for the drug release was studied by measuring UV-vis absorption, FT-IR, and HPLC spectra, which suggested that chlorambucil was released effectively and precisely by manipulating external light conditions. And the introduction of different functional groups made this type of prodrug a good platform to further react with some typical drug carriers and to further form excellent visible light responsive drug delivery systems. Moreover, the drug also could be effectively released under the excitation of two-photon at 800 nm with comparable photorelease efficiencies. The Royal Society of Chemistry 2012.