H-L-TYR(ALL)-OME HCL

Base Information

• Chemical Name: H-L-TYR(ALL)-OME HCL
• CAS No.: 138535-28-1
• Molecular Formula: C13H17NO3.ClH
• Molecular Weight: 271.74000
• Hs Code.: 2922509090
• Mol file: 138535-28-1.mol

Synonyms:O-ALLYL-L-TYROSINE METHYL-ESTER HYDROCHLORIDE;O-ALLYL-L-TYROSINE METHYLESTER HYDROCHLORIDE;O-ALLYL-L-TYROSINE METHYL ESTER HYDROCHLORIDE;

Chemical Property of H-L-TYR(ALL)-OME HCL

Chemical Property:

• PSA: 61.55000
• LogP: 2.79650

Purity/Quality:

97% ^*data from raw suppliers

O-Allyl-L-tyrosine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: O-Allyl-L-tyrosine methyl ester HCl

Technology Process of H-L-TYR(ALL)-OME HCL

There total 3 articles about H-L-TYR(ALL)-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[4-(prop-2-en-1-yloxy)phenyl]-propanoate (147363-23-3) → methyl (2S)-3-(4-allyloxyphenyl)-2-aminopropanoate hydrochloride (138535-28-1)

Guidance literature:

methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[4-(prop-2-en-1-yloxy)phenyl]-propanoate; With trifluoroacetic acid; In dichloromethane; for 16h;

With hydrogenchloride; In methanol; diethyl ether; water; for 0.0833333h;

DOI:10.1016/j.tet.2008.09.031

Reference yield:

methyl (2S)-(4-allyloxyphenyl)-2-aminopropanoate trifluoroacetate (945955-33-9) → methyl (2S)-3-(4-allyloxyphenyl)-2-aminopropanoate hydrochloride (138535-28-1)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; for 0.0833333h;

Reference yield:

methanol (67-56-1) + N-(tert-butyloxycarbonyl)-O-allyl-(S)-tyrosine (127132-38-1) → methyl (2S)-3-(4-allyloxyphenyl)-2-aminopropanoate hydrochloride (138535-28-1)

Guidance literature:

With acetyl chloride; for 3.5h; Reflux; Cooling with ice;

DOI:10.1021/ml4004556

upstream raw materials:

methyl (2S)-(4-allyloxyphenyl)-2-aminopropanoate trifluoroacetate

methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[4-(prop-2-en-1-yloxy)phenyl]-propanoate

methanol

N-(tert-butyloxycarbonyl)-O-allyl-(S)-tyrosine

Downstream raw materials:

methyl (2S,5R)-2-(4-allyloxybenzyl)-3-aza-9-(tert-butoxycarbonylamino)-5-(9H-9-fluorenylmethyloxycarbonylamino)-4-oxononanoate

methyl (2S,5S)-2-(4-allyloxybenzyl)-3-aza-9-(tert-butoxycarbonylamino)-5-(9H-9-fluorenylmethyloxycarbonylamino)-4-oxononanoate

methyl (2S,5R)-2-(4-allyloxybenzyl)-3-aza-5-(9H-9-fluorenylmethyloxycarbonylamino)-4-oxo-8-[N'-(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromen-6-ylsulfonyl)guanidino]octanoate

(S)-2-[(S)-3-(4-allyloxy-phenyl)-2-(4-fluoro-benzenesulfonylamino)-propionylamino]-4-methyl-pentanoic acid

Refernces

• 1、 Halland, Nis,Blum, Horst,Buning, Christian,Kohlmann, Markus,Lindenschmidt, Andreas. "Small macrocycles as highly active integrin α2β1 antagonists". supporting information. p. 193 - 198. Retrieved 2014/03/21.
• 2、 -. "PEPTIDIC COMPOUNDS". Page/Page column 156. . Retrieved 2008/06/13.