13855-74-8

Basic information

• Product Name: 4-chloro-N-(hydroxymethyl)benzamide
• Synonyms: 4-chloro-N-(hydroxymethyl)benzamide
• CAS NO: 13855-74-8
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 13855-74-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 378.5°Cat760mmHg
• Flash Point: 182.7°C
• Appearance: /
• Density: 1.333g/cm³
• Vapor Pressure: 2.1E-06mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: 4-chloro-N-(hydroxymethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(hydroxymethyl)benzamide(13855-74-8)
• EPA Substance Registry System: 4-chloro-N-(hydroxymethyl)benzamide(13855-74-8)

Safety Data

• Hazardous Substances Data: 13855-74-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8ClNO2/c9-7-3-1-6(2-4-7)8(12)10-5-11/h1-4,11H,5H2,(H,10,12)

Upstream product

• 50-00-0 formaldehyd 
• 619-56-7 4-chlorobenzamide 
• 3088-27-5 monomethanolamine 
• 122-01-0 4-chloro-benzoyl chloride 
• 74-11-3 para-chlorobenzoic acid 
• 135158-79-1 4-Trifluoromethyl-benzoic acid (4-chloro-benzoylamino)-methyl ester 
• 135158-80-4 4-Nitro-benzoic acid (4-chloro-benzoylamino)-methyl ester 
• 134814-89-4 4-Methoxy-benzoic acid (4-chloro-benzoylamino)-methyl ester 
• 134814-90-7 4-Chloro-benzoic acid (4-chloro-benzoylamino)-methyl ester 
• 134814-84-9 Benzoic acid (4-chloro-benzoylamino)-methyl ester 

Downstream Products

• 150536-48-4 N-(4-methylphenylthiomethyl)-4-chlorobenzamide 
• 501087-87-2 4-chloro-N-(3,4-diethoxy-phenylsulfanylmethyl)-benzamide 
• 24948-08-1 4-Chloro-N-((1S,2S)-2-hydroxy-cyclohexylmethyl)-benzamide 
• 126675-31-8 (1R,2R)-2-[(4-Chloro-benzylamino)-methyl]-cyclohexanol 
• 150536-43-9 2-(4-chlorophenyl)-4-methyl-4H-1,3-benzothiazine 
• 150536-50-8 2-(4-chlorophenyl)-7-methoxy-4H-1,3-benzothiazine 
• 150536-49-5 2-(4-chlorophenyl)-5-methoxy-4H-1,3-benzothiazine 
• 58379-65-0 2-phenyl-7-methoxy-4H-1,3-benzothiazine 
• 150536-51-9 2-(4-chlorophenyl)-7-methyl-4H-1,3-benzothiazine 
• 150536-47-3 2-(4-chlorophenyl)-6-methyl-4H-1,3-benzothiazine 
• 39104-58-0 4-Chloro-N-[(3-phenyl-thioureido)-methyl]-benzamide 
• 39104-57-9 4-Chloro-N-[(3-phenyl-ureido)-methyl]-benzamide 
• 619-56-7 4-chlorobenzamide 

Relevant articles and documents

Discovery of Novel Antibiotics as Covalent Inhibitors of Fatty Acid Synthesis

The steady increase in the prevalence of multidrug-resistant Staphylococcus aureus has made the search for novel antibiotics to combat this clinically important pathogen an urgent matter. In an effort to discover antibacterials with new chemical structure

Aryl substituted oxadiazine-one compounds as well as preparation method and application thereof

The invention discloses aryl substituted oxadiazine-one compounds as well as a preparation method and an application thereof. The structures of the compounds are represented as formula I. The compounds have novel structures, the preparation process is sim

Rate of formation of N-(hydroxymethyl)benzamide derivatives in water as a function of pH and their equilibrium constants

The third-order rate constants for the pH-dependent formation of the carbinolamides generated from the reaction of formaldehyde and benzamide, 4-chloro, 4-nitro, 4-methyl and 4-methoxybenzamide, are reported. The acid-catalyzed reaction was found to occur via rate-limiting proton transfer, whereas the hydroxide-dependent reaction occurred via a specific-base process. Coupling the rate constants for carbinolamide formation reported herein with the previously established rates for carbinolamide breakdown yielded equilibrium constants for the carbinolamides studied in water.