138571-53-6Relevant academic research and scientific papers
New neplanocin analogues. IX. A practical preparation of (6'R)-6'-C- methylneplanocin A (RMNPA), a potent antiviral agent, and the determination of its 6'-configuration. Diastereoselective deamination by adenosine deaminase
Shuto, Satoshi,Obara, Takumi,Yaginuma, Satoshi,Matsuda, Akira
, p. 138 - 142 (2007/10/03)
We previously synthesized (6'R)- and (6'S)-6'-C-methylneplanocin A's (2a and 2b, respectively), and found that one of them has a potent antiviral activity, though its 6'-configuration has not been confirmed. This report describes the determination of the
New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents
Shuto,Obara,Toriya,Hosoya,Snoeck,Andrei,Balzarini,De Clercq
, p. 324 - 331 (2007/10/02)
Novel neplanocin A analogues modified at the 6'-position, i.e., 6'-deoxy analogues (2, 3, 6, 9, 20), 6'-O-methylneplanocin A (15), and 6'-C- methylneplanocin A's (22a and 22b) have been synthesized and evaluated for their antiviral activity in a wide vari
