138625-63-5

Upstream product

• 98-88-4 benzoyl chloride 
• 534-03-2 serinol 
• 93-58-3 benzoic acid methyl ester 
• 93-89-0 benzoic acid ethyl ester 
• 10144-46-4 N-benzoyl-L-serine methyl ester 
• 892128-51-7 2-benzoylamino-2-(methoxycarbonyl)ethyl benzoate 

Downstream Products

• 71811-34-2 2-benzoylamino-1,3-bis-benzoyloxy-propane 
• 138625-62-4 α-(benzoylamino)acrolein 
• 296766-47-7 N-[cis-2-(2',2'-dimethoxyethyl)-1,3-dioxan-5-yl]benzoylamine 
• 296766-49-9 N,N'-methylenebis[(cis)/(trans)-1,3-dioxan-2,5-diyl]bisbenzamide 
• 296766-64-8 N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl][(trans)-1,3-dioxan-2,5-diyl]bisbenzamide 
• 296766-60-4 N,N'-methylenebis[(2S,4R,5R)/(2S,4S,5S)-4-methyl-1,3-dioxan-2,5-diyl]bisbenzamide 
• 943655-41-2 trans-N-[2-(4'-methylphenyl)-1,3-dioxan-5-yl]benzamide 
• 864954-02-9 cis-N-[2-(4'-nitrophenyl)-1,3-dioxan-5-yl]benzamide 
• 943655-46-7 trans-N-[2-(3'-nitrophenyl)-1,3-dioxan-5-yl]benzamide 
• 296766-57-9 [(trans)-N-2-(2-ethoxyethyl-2-methoxy)-1,3-dioxan-5-yl]benzamide 

Relevant academic research and scientific papers

N-acylation reactions performed in aqueous reaction medium: Screening and optimising of a synthetic step of a process for iodixanol

This contribution presents results from a development and optimisation project concerning a synthetic process for iodixanol. Iodixanol is the "active ingredient" in Visipaque (Nycomed Amersham now Amersham Health) a medical X-ray imaging contrast agent. T

Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes

A new class of 2,5-disubstituted-dioxacycloalkanes were designed and synthesized via stereoselective synthetic method as cancer chemoprevention agents. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Some of these compounds exhibited comparable or better anti-inflammatory activities than that of aspirin suggesting that they can be further developed as potential anti-inflammatory drug lead compounds. In addition, treatment of these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds.

Unexpected selectivity in sodium borohydride reductions of α-substituted esters: Experimental and theoretical studies

The propensity of sodium borohydride to reduce the carbonyl group in eleven α-substituted and two aromatic esters has been investigated by experiments and at the B3LYP/6-31++G(d,p)//HF/6-31G(d,p) level of theory. The chemoselectivities in nine of these reductions have been examined by experiments. Experimental results agree well with the calculated order of activation energies for hydride transfer to the ester carbonyl group. Methyl α-bromoacetate reduces faster than methyl α-fluoroacetate. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

5-Benzoylamino-1,3-dioxacyclanes, the method for preparing the same and their use as PKC inhibitor

The present invention discloses a series of benzoylamino-1,3-dioxacyclane compounds, of which compounds 1-21 were prepared via transacetalisation reaction between N-benzoylaminoglycol and 1,1,3,3-tetramethoxypropane; while compounds 22-48 were prepared vi

Stereoselective transacetalization of 1,1,3,3-tetramethoxypropane and N- benzoylaminodiols

The transacetalization of 1,1,3,3-tetramethoxypropane and an N- benzoylaminodiol provided stereoselectively the corresponding 2,5- disubstituted-1,3-dioxanes. The stereochemistry of the rings formed in the transacetalization depended on the structure of the amino diol, and the ratio of the products depended on the reaction conditions, as expected. This kind of stereoselective transacetalization not only gives a series of useful building blocks but also generates interesting 1,3-dioxanes which target protein kinase C.

Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method

Novel cyclic phosphonate ester inhibitors of MTP are provided which have the structure STR1 wherein R2, L2, A, B, L1, R1 and R5a are as set out herein. These compounds are useful in lowering serum cho

An efficient synthesis of 6-substituted aminohexahydro-1H-1,4-diazepines from 2-substituted aminopropenals

Swern oxidation of 2-substituted amino-1,3-propanediols 20a - d, 38, 41, and 42 smoothly proceeded to give the oxidative dehydration products, 2-substituted aminopropenals 17a - d, 43, 45 and 46, respectively. Reaction of the intriguing 2-substituted amin