13864-76-1

Upstream product

• 14850-89-6 (E)-N'-benzylidenebenzohydrazide 
• 75-36-5 acetyl chloride 
• 100-52-7 benzaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 14850-88-5 benzoylhydrazone of benzaldehyde 
• 108-24-7 acetic anhydride 

Downstream Products

• 14850-88-5 benzoylhydrazone of benzaldehyde 
• 14331-27-2 1-acetyl-2-benzoylhydrazine 
• 100-52-7 benzaldehyde 
• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Oxadiazole based Os(IV) compounds as potential DNA intercalator and cytotoxic agents

Os(IV) compounds and ligands have been synthesized and well characterized. DNA cleavage tendency of compounds has been evaluated using gel electrophoresis and binding behavior has been evaluated by viscosity measurements, absorption titration, fluorescenc

A facile route to the synthesis of 1,3,4-oxadiazoline derivatives

N-Acyl araldehyde hydrazones when treated with Ac2O/pyridine were acetylated and cyclised to 5-substituted 2-aryl-3-acetyl-1,3,4- oxadiazolines in good yield.

Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus

The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies.

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles were designed, synthesized, and tested as inhibitors against human monoamine oxidase (MAO) A and B isoforms. Several compounds, obtained as racemates, were identified as selective MAO-B inhibitors. The enantiomers of some derivatives were separated by enantioselective HPLC and tested. The R-enantiomers always showed the highest activity. Docking study and molecular dynamic simulations demonstrated the putative binding mode. We conclude that these 1,3,4-oxadiazoles derivatives are promising reversible and selective MAO-B inhibitors.

Synthesis, oxidation and dehydrogenation of cyclic N,O- and N,S-acetals. Part III. [1,2] Transformation of N,O-acetals: 3-Acyl-1,3,4-oxadiazolines

(Chemical Equation Presented) Various aldehyde and ketone acylhydrazones are synthesized and, under acylating conditions, cyclized into 3-acyl-1,3,4-oxadiazolines. The scope and limitations of these cyclizations and the possible side reactions (e.g. formation of the open-chain N,O-acylhydrazinocarbinols) are dissected. For the first time, simple, convenient and efficient dehydrogenations of 3-acyl-1,3,4-oxadiazolines to oxadiazoles by treatment with potassium permanganate, or more conveniently, with ammonium cerium(IV) nitrate (CAN) are presented. CAN oxidation of 2,2-disubstituted 3-acyl-1,3,4-oxadiazolines, as well as that of aldehyde diacylhydrazones (open-chain isomers of 2,5-disubstituted 3-acyl-1,3,4- oxadiazolines) regenerates the parent carbonyl compounds.

Preparation and Spectroscopic Properties of 3-Acyl-1,3,4-oxadiazolines

1,3,4-Oxadiazolines I, in which substituent groups R1 through R4 may be varied through appropriate choice of precursor reactants, can be prepared in good yields and purity by convenient cyclizations of acylhydrazones with anhydrides.The reactions can be e

The Mechanism of Cyclization of 1,4-Diaryl-1-azido-2,3-diazabuta-1,3-dienes to Tetrazoles. Imidoyl Azides stabilized by Slow Nitrogen Inversion

The imidoyl azides (9) are stabilized in the open chain azido form because of their configuration (which is Z about the C=N bond) and slow ZE isomerization.The rates of conversion of the azides (9) into the isomeric tetrazoles (12) have been measused and