302924-67-0

Basic information

• Product Name: 1-BOC-4-(4-METHOXYPHENYL)-4-HYDROXYPIPERIDINE
• Synonyms: 1-BOC-4-(4-METHOXYPHENYL)-4-HYDROXYPIPERIDINE
• CAS NO: 302924-67-0
• Molecular Formula: C₁₇H₂₅NO₄
• Molecular Weight: 307.388
• Mol File: 302924-67-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BOC-4-(4-METHOXYPHENYL)-4-HYDROXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(4-METHOXYPHENYL)-4-HYDROXYPIPERIDINE(302924-67-0)
• EPA Substance Registry System: 1-BOC-4-(4-METHOXYPHENYL)-4-HYDROXYPIPERIDINE(302924-67-0)

Safety Data

• Hazardous Substances Data: 302924-67-0(Hazardous Substances Data)

Usage

General Description

1-BOC-4-(4-METHOXYPHENYL)-4-HYDROXYPIPERIDINE is a chemical compound belonging to the piperidine class. It is a derivative of piperidine with a tert-butoxycarbonyl (BOC) protecting group at the nitrogen atom and a 4-(4-methoxyphenyl) substituent at the 4-position. 1-BOC-4-(4-METHOXYPHENYL)-4-HYDROXYPIPERIDINE is a hydroxy piperidine derivative and is widely used in chemical and pharmaceutical research as an intermediate for the synthesis of various organic compounds. The BOC protecting group is commonly used to temporarily mask the amine group in order to control the reactivity and selectivity during chemical reactions. The 4-(4-methoxyphenyl) substituent adds specific properties to the compound, making it useful in the development of new drugs and other biologically active molecules.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 213596-33-9 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 5938-16-9 4-(4-methoxylphenyl)pyridine 
• 6748-48-7 4-(4-methoxyphenyl)-piperidinehydrochloride 
• 143682-48-8 3-{4-[4-(4-Methoxy-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-butyl}-1H-indole 
• 1026561-42-1 4-(1H-Indol-3-yl)-1-[4-(4-methoxy-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-butan-1-one 
• 725739-54-8 4-(4-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-sulfonyl chloride 
• 59954-73-3 4-(4-methoxyphenyl)-1,2,3,6-tetrahydro-pyridine 
• 138647-51-5 4-(4-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 143017-63-4 4-(4-methoxyphenyl)-1,2,3,6-tetrahydropyridine hydrochloride 

Relevant articles and documents

Bulky N-Heterocyclic-Carbene-Coordinated Palladium Catalysts for 1,2-Addition of Arylboron Compounds to Carbonyl Compounds

The synthesis of primary, secondary, and tertiary alcohols by the 1,2-addition of arylboronic acids or boronates to carbonyl compounds, including unactivated ketones, using novel bulky yet flexible N-heterocyclic carbene (NHC)-coordinated 2,6-di(pentan-3-yl)aniline (IPent)-based cyclometallated palladium complexes (CYPs) as catalysts is reported. The PhS-IPent-CYP-catalyzed reactions are efficient at low catalyst loadings (0.02–0.3 mol% Pd), and the exceptional catalytic activity for 1,2-addition is attributed to the steric bulk of the NHC ligand. These reactions can yield a wide range of functionalized benzylic alcohols that are difficult to synthesize by classical protocols using highly active organomagnesium or lithium reagents.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

There is a significant unmet medical need for more efficacious and rapidly acting antidepressants. Toward this end, negative allosteric modulators of the N-methyl-d-aspartate receptor subtype GluN2B have demonstrated encouraging therapeutic potential. We

The use of organolithium reagents for the synthesis of 4-aryl-2-phenylpyridines and their corresponding iridium(III) complexes

A versatile palladium-free route for the synthesis of 4-aryl-substituted phenylpyridines (ppy), starting from tert-butyl 4-oxopiperidine-1-carboxylate, is reported. Reaction with an aryllithium, followed by trifluoroacetic acid dehydration/deprotection and oxidation with 2-iodoylbenzoic acid and finally phenylation, gave 4 ligands (L1-4H): 2,4-diphenylpyridine, 4-(4-methoxyphenyl)-2-phenylpyridine, 2-phenyl-4-(o-tolyl)pyridine and 4-mesityl-2-phenylpyridine. These ligands were coordinated to iridium to give the corresponding Ir(L)2(A) complexes (Ir1-7), where A = ancillary ligand acetylacetate or 2-picolinate. This was used to demonstrate that, through a combination of ancillary ligand choice and torsional twisting between the 4-aryl substituents of the ppy ligands, it is possible to tune the phosphorescent emission of the complexes in the range 502-560 nm.