59954-73-3

Basic information

• Product Name: 4-(4-METHOXY-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE
• Synonyms: 4-(4-METHOXY-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE
• CAS NO: 59954-73-3
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.2536
• Mol File: 59954-73-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-METHOXY-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXY-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE(59954-73-3)
• EPA Substance Registry System: 4-(4-METHOXY-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE(59954-73-3)

Safety Data

• Hazardous Substances Data: 59954-73-3(Hazardous Substances Data)

Upstream product

• 5938-16-9 4-(4-methoxylphenyl)pyridine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 41979-39-9 4-piperidone hydrochloride 
• 158984-57-7 1-(4-hydroxy-4-(4-methoxyphenyl)piperidin-1-yl)ethanone 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 302924-67-0 tert-butyl 4-hydroxy-4-(4-methoxyphenyl)-1-piperidinecarboxylate 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 138647-51-5 4-(4-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 107336-07-2 2-{2-[4-(4-Methoxy-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-ethoxy}-benzaldehyde 
• 107336-08-3 2-{3-[4-(4-Methoxy-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-propoxy}-benzaldehyde 
• 725739-54-8 4-(4-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-sulfonyl chloride 
• 548771-27-3 4-(4-Methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 4-(5-methyl-pyridin-2-ylmethyl)-phenyl ester 
• 1574730-89-4 2-(2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethyl)isoindoline-1,3-dione 
• 1574730-64-5 2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine 
• 1394387-87-1 N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine 
• 1350737-69-7 4-(4-methoxyphenyl)-2-phenylpyridine 
• 5938-16-9 4-(4-methoxylphenyl)pyridine 
• 1382321-69-8 2-{[4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl]-methyl}benzofuran-7-carboxamide 
• 1134111-38-8 C₁₃H₁₇NO₃S 
• 71916-59-1 4-(4-methoxyphenyl)-1,2,5,6-tetrahydro-1-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]pyridine 
• 35268-56-5 4'-{2-[4-(p-methoxyphenyl)-3,6-dihydro-1(2H)-pyridyl]ethoxy}acetanilide 
• 158984-50-0 3-[4-(4-methoxyphenyl)-1,2,3,6-tetrahydropyridin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

The use of organolithium reagents for the synthesis of 4-aryl-2-phenylpyridines and their corresponding iridium(III) complexes

A versatile palladium-free route for the synthesis of 4-aryl-substituted phenylpyridines (ppy), starting from tert-butyl 4-oxopiperidine-1-carboxylate, is reported. Reaction with an aryllithium, followed by trifluoroacetic acid dehydration/deprotection and oxidation with 2-iodoylbenzoic acid and finally phenylation, gave 4 ligands (L1-4H): 2,4-diphenylpyridine, 4-(4-methoxyphenyl)-2-phenylpyridine, 2-phenyl-4-(o-tolyl)pyridine and 4-mesityl-2-phenylpyridine. These ligands were coordinated to iridium to give the corresponding Ir(L)2(A) complexes (Ir1-7), where A = ancillary ligand acetylacetate or 2-picolinate. This was used to demonstrate that, through a combination of ancillary ligand choice and torsional twisting between the 4-aryl substituents of the ppy ligands, it is possible to tune the phosphorescent emission of the complexes in the range 502-560 nm.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein X1, X2, W, R1 to R5, L and m have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.