138715-77-2Relevant academic research and scientific papers
A benzene-bridged divanadium complex-early transition metal catalyst for alkene alkylarylation with PhI(O2CR)2viadecarboxylation
Zhang, Lei,Zhou, Hongfei,Bai, Shaokun,Li, Shaodan
supporting information, p. 3201 - 3206 (2021/03/16)
The synthesis, structure and catalytic activity of a benzene-bridged divanadium complex were comprehensively studied. The reduction of (Nacnac)VCl2(1) (Nacnac = (2,6-iPr2C6H3NCMe)2HC) supported by β-diketiminate with potassium graphite (KC8) by employing benzene as the solvent allows access to the benzene-bridged inverted-sandwich divanadium complex (μ-η6:η6-C6H6)[V(Nacnac)]2(2a), which can catalyze alkene alkylarylation with hypervalent iodine(iii) reagents (HIRs)viadecarboxylation to generate regioselectively diverse indolinones. Furthermore, the mild nature of this reaction was amenable to a wide range of functionalities on alkenes and HIRs. Mechanistic studies revealed a relay sequence of decarboxylative radical alkylation/radical arylation/oxidative re-aromatization.
An Efficient Approach to Functionalized Indoles from λ3-Iodanes via Acyloxylation and Acyl Transfer
Jeyakannu, Palaniraja,Chandru Senadi, Gopal,Chiang, Chun-Hsien,Kumar Dhandabani, Ganesh,Chang, Yu-Ching,Wang, Jeh-Jeng
supporting information, p. 2911 - 2920 (2020/06/02)
Versatile role of λ3-iodanes has been identified between the reaction of hydroquinone and β-enaminones for the synthesis of 5-acyloxy-4-hydroxy indoles. The reaction is proposed to proceed through an intermolecular C?C bond formation, intramole
Direct β-C(sp3)-H Acetoxylation of Aliphatic Carboxylic Acids
Ghosh, Kiron K.,Uttry, Alexander,Koldemir, Aylin,Ong, Mike,Van Gemmeren, Manuel
supporting information, p. 7154 - 7157 (2019/09/03)
The controlled construction of defined oxidation patterns is one of the key aspects in the synthesis of natural products and bioactive molecules. Towards this goal, we herein report a novel protocol for the Pd-catalyzed direct β-C(sp3)-H acetoxylation of aliphatic carboxylic acids. The protocol enables the use of free carboxylic acids in one step and without the need of introducing specialized strong directing groups. In our studies, we found that the use of a "traceless base" was crucial for the development of a synthetically useful transformation. Furthermore, the synthetic utility of the products obtained was demonstrated by their use in subsequent transformations.
