1387552-55-7Relevant academic research and scientific papers
Synthesis and characterization of polyphenylenes with polypeptide and poly(ethylene glycol) side chains
Akbulut, Huseyin,Endo, Takeshi,Yamada, Shuhei,Yagci, Yusuf
, p. 1786 - 1793 (2015)
We report a novel approach for fabrication of multifunctional conjugated polymers, namely poly(p-phenylene)s (PPPs) possessing polypeptide (poly-l-lysine, PLL) and hydrophilic poly(ethylene glycol) (PEG) side chains. The approach is comprised of the combination of Suzuki coupling and in situ N-carboxyanhydride (NCA) ring-opening polymerization (ROP) processes. First, polypeptide macromonomer was prepared by ROP of the corresponding NCA precursor using (2,5-dibromophenyl)methanamine as an initiator. Suzuki coupling reaction of the obtained polypeptide and PEG macromonomers both having dibromobenzene end functionality using 1,4-benzenediboronic acid as the coupling partner in the presence of palladium catalyst gave the desired polymer. A different sequence of the same procedure was also employed to yield polymer with essentially identical structure. In the reverse sequence mode, low molar mass monomer (2,5-dibromophenyl)methanamine, and PEG macromonomer were coupled with 1,4-benzenediboronic acid in a similar way followed by ROP of the L-Lysine NCA precursor through the primary amino groups of the resulting polyphenylene.
Useful synthetic method of polypeptides with well-defined structure by polymerization of activated urethane derivatives of α-amino acids
Yamada, Shuhei,Koga, Koichi,Endo, Takeshi
experimental part, p. 2527 - 2532 (2012/07/17)
A facile polymerization strategy for synthesis of polypeptides with well-defined structure using urethane derivatives of α-amino acids in the presence of amine is reported. N-(phenoxycarbonyl) α-amino acid was polymerized at 60°C in N,N-dimethyl acetamide
