1676-86-4

Usage

Uses

Used in Pharmaceutical Industry:
N6-Carbobenzoxy-L-lysine N-Carboxyanhydride is used as a building block for the synthesis of Polylysine, which has potential applications in the pharmaceutical industry. Polylysine exhibits antimicrobial properties, making it a valuable compound for developing new drugs to combat infections.
Used in Agriculture:
In the agricultural industry, N6-Carbobenzoxy-L-lysine N-Carboxyanhydride is used as a precursor for Polylysine, which has demonstrated its effectiveness in inhibiting fungal penetration and polyphenol formation in susceptible sweet potatoes infected with C. fimbriata. It also promotes callus formation in resistant sweet potatoes and inhibits the infection of tomato cuttings by F. lycopersici, thus contributing to crop protection and disease management.
Used in Biochemical Research:
N6-Carbobenzoxy-L-lysine N-Carboxyanhydride is utilized as a research tool in biochemical studies. Its role in the synthesis of Polylysine allows scientists to explore the properties and potential applications of this synthetic poly-α-amino acid, furthering our understanding of its biological activities and possible uses in various fields.

Upstream product

• 405-39-0 N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 75-44-5 phosgene 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 657-27-2 L-Lysine hydrochloride 
• 56-87-1 L-lysine 
• 501-53-1 benzyl chloroformate 
• 1387552-55-7 C₂₁H₂₄N₂O₆ 
• 32302-83-3 N-ε-benzyloxycarbonyl lysine 
• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 102495-95-4 N⁶-benzyloxycarbonyl-L-lysine hydrazide 
• 59515-43-4 N^ε-benzyloxycarbonyl-L-lysine ethyl ester hydrochloride 
• 54745-15-2 Nps-Lys(Z)-NCA 
• 116586-26-6 (2S,3aS,7aS)-1-(N⁶-benzyloxycarbonyl-L-lysyl-γ-D-glutamyl)octahydro-1H-indole-2-carboxylic acid 
• 55226-85-2 tetra-(N-carbobenzoxy-L-lysine) 

Relevant academic research and scientific papers

Immunostimulation of tumor microenvironment by targeting tumor-associated macrophages with hypoxia-responsive nanocomplex for enhanced anti-tumor therapy

Tumor-associated macrophages (TAMs), which dampen the therapeutic efficacy of cancer immunotherapy, are the key players in the immunosuppressive tumor microenvironment (TME). Therefore, reprogramming TAMs into tumoricidal M1 macrophages possesses consider

Biodegradable supramolecular micellesviahost-guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones

Biodegradable supramolecular micelles were prepared exploiting the host-guest interaction of cyclodextrin and adamantane. Cyclodextrin-initiated polypeptides acted as the hydrophilic corona, whereas adamantane-terminated polycaprolactones served as the hydrophobic core.

On-POM Ring-Opening Polymerisation of N-Carboxyanhydrides

The ring-opening polymerisation of α-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)—redox-active molecular metal-oxide anions—can serve as inorganic scaffold initiators for such NCA polymerisations. This “On-POM polymerisation” strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)–POM hybrid derivatives that can be used to prevent biofilm formation. This versatile “On-POM polymerisation” method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials.

Cholesteroled polymer (Chol-b-Lys)-based nanoparticles (CL-NPs) confer antibacterial efficacy without resistance

It is imperative to develop innovative and efficient antibacterial agents, on account of the mounting prevalence of complicated infections induced by multidrug-resistant bacteria. In this work, Chol-b-Lys nanoparticles (CL-NPs) with a diameter of 304.9 nm

Alendronate-functionalized hypoxia-responsive polymeric micelles for targeted therapy of bone metastatic prostate cancer

Bone metastasis is one of the leading causes of cancer-related death and remains incurable in spite of great efforts. Bone-targeted nanoparticle-based drug carriers can overcome the difficulties in delivering therapeutic agents to metastatic bone and endo

POLYMER COMPOSITE FOR HELICOBACTER PYLORI RECOGNITION AND COMPOSITION FOR PHOTODYNAMIC THERAPY COMPRISING SAME

The present invention relates to a polymer complex for recognizing Helicobacter pylori and its uses, and in more detail, a water-soluble polymer-photosensitizer complex in which sialyllactose, which selectively binds to the surface of Helicobacter pylori,

Theranostic nanoparticles enabling the release of phosphorylated gemcitabine for advanced pancreatic cancer therapy

Gemcitabine (GEM) has been the recommended first-line drug for patients with pancreatic ductal adenocarcinoma cancer (PDAC) for the last twenty years. However, GEM-based treatment has failed in many patients because of the drug resistance acquired during

Polyionic type micelle shielding system with electric charge turnover function and preparation method thereof

The invention provides a polyionic type micelle shielding system with reversible charges. The polyionic type micelle shielding system is formed by a compound shown as formula (III) and cis-diamminedichloroplatinum through coordination. According to the polyionic type micelle shielding system with the reversible charges, cis-diamminedichloroplatinum is supported under a coordination action, a support material is good in biocompatibility and solubility, the nano-support is enriched at a tumor tissue part through an EPR (enhanced permeability and retention effect), a shell with a shielding capability is removed under the condition of pH at the tumor tissue part, a positively charged cis-diamminedichloroplatinum supported core is exposed, endocytosis is facilitated by the positively charged core, and after the cis-diamminedichloroplatinum supported core enters a cell, the drug cis-diamminedichloroplatinum with anti-tumor performance is released by the cis-diamminedichloroplatinum supportedcore.

Lung gene delivery system and preparation method and application thereof

The invention provides a lung gene delivery system as well as a preparation method and application thereof. The lung gene delivery system has the capability of efficiently overcoming mucus layers andcell membrane barriers. RBP and cis-aconitic anhydride a

Preparation method and application of nanoparticle of ribonucleoprotein compound capable of achieving tumor targeted delivery

The invention discloses a preparation method and application of nanoparticles of a ribonucleoprotein compound capable of achieving tumor targeted delivery. The nanoparticles are formed by self-assembly of a polymer with tumor microenvironment responsivene