138950-21-7

Basic information

• Product Name: Benzenemethanol, a-(1-chloro-2,2,2-trifluoroethyl)-
• CAS NO: 138950-21-7
• Molecular Formula: C9H8ClF3O
• Molecular Weight: 224.61
• Mol File: 138950-21-7.mol

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(1-chloro-2,2,2-trifluoroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(1-chloro-2,2,2-trifluoroethyl)-(138950-21-7)
• EPA Substance Registry System: Benzenemethanol, a-(1-chloro-2,2,2-trifluoroethyl)-(138950-21-7)

Safety Data

• Hazardous Substances Data: 138950-21-7(Hazardous Substances Data)

Upstream product

• 103654-96-2 1-(α,α-dichloro-β,β,β-trifluoroethyl)benzylalcohol 
• 100-52-7 benzaldehyde 
• 151-67-7 1,1,1-trifluoro-2-bromo-2-chloroethane 
• 306-83-2 1,1,1-trifluoro-2,2-dichloroethane 

Relevant articles and documents

Synthesis of fluorine compounds using zinc complex of halothane

We have reported the Grignard reaction of Halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane (1), with ketones gave unexpected products, α-(1-bromo-1-chloro-2,2,2-trifluoroethyl)alcohols (4) at a low temperature. However, this reaction hardly proceeded with aldehydes. Now, we found the reaction of 1 with aldehydes in the presence of zinc gave not only products of type 4, but α-(1-chloro-2,2,2-trifluoroethyl)alcohols (3), the expected type of products, under mild conditions in good to moderate yields.

Synthetic utility of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane): the reaction between HCFC-123 and aldehydes using zinc

HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) reacted with zinc and aldehydes to afford predominantly either 1-substituted 2-chloro-3,3-difluoro-2-propen-1-ols or 1-substituted 2,2-dichloro-3,3,3-trifluoro-1-propanols.The reactions proceeded via 1,1-dichloro-2,2,2-trifluoroethylzinc chloride as an organozinc intermediate. - Keywords: 2,2-Dichloro-1,1,1-trifluoroethane; Reaction; Aldehydes; Zinc; 1,1-Dichloro-2,2,2-trifluoroethylzinc chloride

Electroreductive coupling of halofluoro compounds with aldehydes

Electroreductive intermolecular coupling of halofluoro compounds such as 1,1,1-trichloro-2,2,2-trifluoroethane, methyl chlorodifluoroacetate, and perfluoroalkyl halides with aldehydes took place effectively in the presence of chlorotrimethylsilane and one of the coupling products, 2,2-dichloro-3,3,3-trifluoro-1-phenyl-1-propranol, was selectively convertible to a variety of compounds with using the electroreduction as a key reaction.