138998-47-7

Basic information

• Product Name: ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate
• Synonyms: ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate
• CAS NO: 138998-47-7
• Molecular Weight: 319.256
• Mol File: 138998-47-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 381.5±42.0 °C(Predicted)
• Density: 1.324±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate(138998-47-7)
• EPA Substance Registry System: ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate(138998-47-7)

Safety Data

• Hazardous Substances Data: 138998-47-7(Hazardous Substances Data)

Usage

Uses

α-[(Dimethylamino)methylene]-2,3,4,5-tetrafluoro-β-oxo-benzenepropanoic Acid Ethyl Ester is used in the synthesis of the drug Levofloxacin (L360000), which is a S-(-) form of Ofloxacin (O245750), an antibiotic used against gram-negative organisms.

Upstream product

• 94695-50-8 ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1117-37-9 ethyl (E)-3-(dimethylamino)acrylate 
• 94695-48-4 2,3,4,5-tetrafluorobenzoyl chloride 
• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 

Downstream Products

• 783366-04-1 C₁₈H₁₂ClF₄NO₄ 
• 889655-44-1 C₂₆H₁₅F₄NO₆ 
• 100828-09-9 ethyl 3-(2-hydroxyanilino)-2-(2,3,4,5-tetrafluoro)benzoylacrylate 
• 783365-84-4 ethyl 2-(2',3',4',5'-tetrafluorobenzoyl)-3-(2,3-diaminonaphthyl)-prop-2-enoate 
• 216501-14-3 Ethyl 3-((1-Hydroxy(2-naphthyl))amino)-2-((2,3,4,5-tetrafluorophenyl)carbonyl)prop-2-enoate 
• 1017903-36-4 C₂₂H₁₅F₄NO₇S 
• 237425-18-2 C₂₄H₁₅F₄NO₅ 
• 783366-36-9 ethyl 2-(2',3',4',5'-tetrafluorobenzoyl)-3-(N-(4-hydroxy-2-aminophenoxazole))-prop-2-enoate 
• 783366-01-8 C₁₈H₁₂ClF₄NO₄ 
• 1211517-53-1 ethyl 1-(2-ethoxy-2-oxo-1-phenylethyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1239015-74-7 ethyl 1-(1-ethoxy-1-oxo-3-phenylpropan-2-yl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1211517-43-9 1-(carboxy(phenyl)methyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Preparation method of levofloxacin and intermediates thereof

The invention relates to a preparation method of levofloxacin and intermediates thereof, and belongs to the field of medicinal chemistry. The preparation method comprises the following steps of: carrying out amino substitution and ring closing reaction on an intermediate substrate to integrate a plurality of intermediates into a one-pot reaction, and hydrolyzing under an acidic condition to obtainlevofloxacin. According to the method provided by the invention, the intermediates do not need to be separated, the reaction operation is simplified, the production period is greatly shortened, multiple times of after-treatment are not needed, emission of three wastes is reduced, the method is more environmentally friendly, the reaction yield is increased compared with the prior art, and the method is suitable for industrial amplification.

Improved method of preparation process of oxo-fluoro cyclization ester or levo-oxo-fluoro cyclization ester

The invention discloses an improved method of a preparation process of oxo-fluoro cyclization ester or levooxo-fluoro cyclization ester. Existing preparation methods of some levofloxacin intermediateshave many side reactions and are low in yield. According to the technical scheme in the invention, by means of 2,3,4,5-tetrafluorobenzoyl chloride, N,N-dimethylaminoethyl acrylate and (L-)aminopropanol as starting raw materials and toluene and N, N-dimethylformamide added with a water removal agent organic ester or anhydride as solvents, the oxygen-fluorine cyclization ester is prepared through aone-pot reaction. According to the method, organic ester or anhydride is added, so that the loss of raw materials and the generation of by-products are reduced, the reaction yield is increased, the product quality is ensured, and the yield of the (L-)oxo-fluoro cyclization ester can be increased from 75-80% to about 90%.

Method for preparing high-quality levofloxacin hydrochloride

The invention provides a method for preparing high-quality levofloxacin hydrochloride. The method comprises the following steps: preparation of 3-(2-hydroxy-1-methyl-ethylamino)-2-(2,3,4,5-tetrafluorobenzoyl)-ethyl acrylate, preparation of levo naphthenic acid and preparation of levofloxacin hydrochloride; the method is concise, the production cost is low, the product yield is high, quality is good, the method has the advantages of economic performance and environmental protection, three waste discharge capacity is little, effective separating and recycling on most by-product can be simultaneously realized, the method is convenient for industrial production, and has large popularization meaning.