70272-01-4

Basic information

• Product Name: 2-Propenoic acid, 3-amino-3-phenyl-, methyl ester
• CAS NO: 70272-01-4
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol File: 70272-01-4.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-amino-3-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-amino-3-phenyl-, methyl ester(70272-01-4)
• EPA Substance Registry System: 2-Propenoic acid, 3-amino-3-phenyl-, methyl ester(70272-01-4)

Safety Data

• Hazardous Substances Data: 70272-01-4(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 96-32-2 bromoacetic acid methyl ester 
• 100-47-0 benzonitrile 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 

Downstream Products

• 72569-96-1 methyl (Z)-3-acetylamino-3-phenylacrylate 
• 1196876-25-1 C₁₆H₁₇NO₄ 
• 13901-70-7 dimethyl 2,5-diphenyl-1H-pyrrole-3,4-dicarboxylate 
• 1346526-97-3 methyl 2-methyl-4-phenyloxazole-5-carboxylate 
• 1346526-79-1 methyl 4-phenyl-2-(trifluoromethyl)oxazole-5-carboxylate 
• 526213-58-1 methyl 2,4-diphenyloxazole-5-carboxylate 
• 1404376-58-4 (E)-1-amino-3-methoxy-3-oxo-1-phenylprop-1-en-2-yl benzoate 
• 1404376-59-5 (Z)-1-amino-3-methoxy-3-oxo-1-phenylprop-1-en-2-yl benzoate 
• 1616563-23-5 methyl 4-hydroxy-5-oxo-2-phenyl-4-(trifluoromethyl)-4,5-dihydro-1H-pyrrole-3-carboxylate 
• 54624-52-1 7-phenylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 1018071-63-0 methyl 2-phenylquinoline-3-carboxylate 
• 1335135-19-7 2,2,6,6-tetramethyl-1-(trifluoromethoxy)piperidine 
• 112630-37-2 2,5-Diphenyl-2H-1,2,3-triazol-4-carbonsaeuremethylester 
• 37088-66-7 (3S)-methyl 3-amino-3-phenylpropanoate 

Relevant articles and documents

Tetrasubstituted 1,3-Enynes by Gold-Catalyzed Direct C(sp2)-H Alkynylation of Acceptor-Substituted Enamines

A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp2)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance.

Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters

A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of new C-S, C-N, and N-S bonds. The strategy provides high selectivity for the synthesis of thiazoles/isothiazoles, which have vital applications in drug discovery and development.

Synthesis of trifluoromethylated 2H-azirines through Togni reagent-mediated trifluoromethylation followed by PhIO-mediated azirination

The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2H-azirines by an iodosobenzene (PhIO)-mediated intramolecular azirination in a one-pot process.