13901-76-3

Upstream product

• 28544-45-8 N-benzoyl-N-methylphenylglycine 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 61802-83-3 N-methyl-N-benzylbenzamide 
• 98-86-2 acetophenone 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 138073-15-1 N-Methyl-N-(phenyl-trimethylsilanyl-methyl)-benzamide 

Downstream Products

• 72572-67-9 (4-Hydroxymethyl-1-methyl-2,5-diphenyl-1H-pyrrol-3-yl)-methanol 

Relevant academic research and scientific papers

Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines

A conceptually novel method for the preparation of pyrrole is described by electrochemical-oxidation-induced intermolecular annulation via enamines. In a simple undivided cell, based on a sodium acetate-facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant-free condition. This electrosynthetic approach providing an environmentally benign protocol for C?C bond cross-coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality.

A one-step route to azomethine ylides via chloroiminium salts

A new, one-step procedure for the generation of azomethine ylides, 4 and 20, via chloroiminium salts, 3 and 19, is reported. The generation of the azomethine ylides was confirmed by their trapping with dimethyl acetylenedicarboxylate (DMAD) which, upon spontaneous 1,4-dehydrochlorination, gave the corresponding pyrroles 17 and 21.

Novel generation of azomethine ylide from N-(α-silylbenzyl)amide by silicon shift: An equivalent of nitrile ylide

Azomethine ylides were generated from N-(α-silylbenzyl)amides by thermal silicon shift to the oxygen and trapped with dipolarophiles to give the same products as those from the corresponding nitrile ylides via elimination of silanol.

THE USE OF N-ETHYL-N'-DIMETHYLAMINOPROPYLCARBODIIMIDE OR SILICON TETRACHLORIDE IN PYRROLE SYNTHESES.

Two methods are used for mesoionic oxazolone formation in the synthesis of pyrroles in 1,3-dipolar cycloaddition reactions.N-ethyl-N'-dimethylaminopropylcarbodiimide or silicon tetrachloride are used to activate the N-acylamino acid.

Synthesis and antileukemic activity of 1-methyl-2,5-diphenyl-3,4-bis(hydroxymethyl)-, 1,2,3-triphenyl-4,5-bis(hydroxymethyl)-, and 1-methyl-2,3-diphenyl-4,5-bis(hydroxymethyl)pyrrole bis(N-methylcarbamate)

The synthesis for the bis(N-methylcarbamates) 3, 4a, 4b, and 5 are described. All four compounds were active in the in vivo P388 lymphocytic leukemia assay, with 3 being the most active.