1392113-91-5Relevant articles and documents
Amphiphilic tobramycin analogues as antibacterial and antifungal agents
Shrestha, Sanjib K.,Fosso, Marina Y.,Green, Keith D.,Garneau-Tsodikova, Sylvie
, p. 4861 - 4869 (2015/09/01)
In this study, we investigated the in vitro antifungal activities, cytotoxicities, and membrane-disruptive actions of amphiphilic tobramycin (TOB) analogues. The antifungal activities were established by determination of MIC values and in time-kill studie
6″-thioether tobramycin analogues: Towards selective targeting of bacterial membranes
Herzog, Ido M.,Green, Keith D.,Berkov-Zrihen, Yifat,Feldman, Mark,Vidavski, Roee R.,Eldar-Boock, Anat,Satchi-Fainaro, Ronit,Eldar, Avigdor,Garneau-Tsodikova, Sylvie,Fridman, Micha
, p. 5652 - 5656 (2012/08/28)
Amphiphilic tobramycin analogues with potent antibacterial activity against tobramycin-resistant bacteria were synthesized. Most analogues were found to be less prone to deactivation by aminoglycoside-modifying enzymes than tobramycin. These compounds tar