13924-95-3

Basic information

• Product Name: 5-Hydroxypyrazine-2-carboxylic acid methyl ester
• Synonyms: CBI-BB ZERO/008486;5-HYDROXY-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER;METHYL 5-HYDROXYPYRAZINE-2-CARBOXYLATE;5-HYDROXY-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 95%;Methyl 5-oxo-4,5-dihydro-2-pyrazinecarboxylate;Methyl 5-hydropyrazine-2-carboxylate;5-Hydrocy-pyrazine-2-carboxylic acid methyl ester;2-Hydroxy-5-(methoxycarbonyl)pyrazine, 2-Hydroxy-5-(methoxycarbonyl)-1,4-diazine
• CAS NO: 13924-95-3
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12
• EINECS: 1312995-182-4
• Product Categories: Pyrazine;Heterocycles
• Mol File: 13924-95-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 183-185 °C
• Boiling Point: 424.1 °C at 760 mmHg
• Flash Point: 210.3 °C
• Appearance: /
• Density: 1.39
• Vapor Pressure: 8.58E-08mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.55±0.40(Predicted)
• CAS DataBase Reference: 5-Hydroxypyrazine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxypyrazine-2-carboxylic acid methyl ester(13924-95-3)
• EPA Substance Registry System: 5-Hydroxypyrazine-2-carboxylic acid methyl ester(13924-95-3)

Safety Data

• Hazardous Substances Data: 13924-95-3(Hazardous Substances Data)

Usage

Uses

5-Hydroxypyrazine-2-carboxylic Acid Methyl Ester is a metabolite of Pyrazinamide (P840600), an antibacterial (tuberculostatic).

InChI:InChI=1/C6H6N2O3/c1-11-6(10)4-2-8-5(9)3-7-4/h2-3H,1H3,(H,8,9)

Upstream product

• 77168-76-4 3-carbamoyl-1,6-dihydro-6-oxo-2-pyrazinecarboxylic acid 
• 57005-60-4 1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile 
• 13924-96-4 4,5-dihydro-5-oxo-2-pyrazinecarboxamide 
• 67-56-1 methanol 
• 34604-60-9 4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid 
• 34604-60-9 5-hydroxypyrazinoic acid 

Downstream Products

• 77168-80-0 5,6-dihydroxy-2-pyrazinecarboxylic acid 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 
• 38789-75-2 methyl 5-methoxypyrazine-2-carboxylate 
• 1421502-62-6 [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone 
• 1421502-74-0 C₃₂H₂₅F₂N₇O₃ 
• 1421503-72-1 5-(2-fluoro-phenoxy)pyrazine-2-carboxylic acid methyl ester 
• 1017603-80-3 5-(piperidin-1-yl)pyrazine-2-carboxylic acid methyl ester 
• 1421502-64-8 {2-[6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1H-indazol-3-yl]-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl}-(5-piperidin-1-yl-pyrazin-2-yl)methanone sodium salt 
• 1210707-88-2 5-(piperidin-1-yl)pyrazine-2-carboxylic acid 
• 210037-58-4 5-bromopyrazine-2-carboxylic acid methyl ester 

Relevant articles and documents

N-(HETEROCYCLYL AND HETEROCYCLYLALKYL)-3-BENZYLPYRIDIN-2-AMINE DERIVATIVES AS SSTR4 AGONISTS

Disclosed are compounds of Formula (1), and pharmaceutically acceptable salts thereof, wherein n, R1, R4, R5, R6, R7, R8, R9, R10, R11, R14, Xsu

NOVEL PHENYLPYRROLE DERIVATIVE

The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula -V-NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

Anticoccidials. VII. Synthesis of 4,5 dihydro 5 oxo 2 pyrazinecarboxylic acid 1-oxides

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