139258-87-0Relevant academic research and scientific papers
Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM
Lu, Kui,Huang, Mengwei,Xiang, Zheng,Liu, Yongxiang,Chen, Jiahua,Yang, Zhen
, p. 1193 - 1196 (2007/10/03)
A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally divers
Synthesis and reactivity of ω-aldehydophosphoranes; application to the preparation of α,β-unsaturated lactones.
Floc'h, Y. Le,Yvergnaux, F.,Toupet, L.,Gree, R.
, p. 742 - 759 (2007/10/02)
α,β-Unsaturated lactones 1 (n = 1 to 7) and symmetrical unsaturated macrodiolides 2 are obtained by a Wittig reaction using ω-aldehydophosphoranes under high dilution conditions.The corresponding phosphonium salts are prepared in 3 steps from commercially available ω-diols.This methodology is applied to the synthesis of an unsaturated macrolide, a precursor of Patulolid A and Patulolid C. Key words: intramolecular Wittig reaction / ω-aldehydophosphoranes / unsaturated lactones / unsaturated dilactones
