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1393127-04-2

ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1393127-04-2 Structure

  • Basic information

    1. Product Name: ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate
    2. Synonyms: ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate
    3. CAS NO:1393127-04-2
    4. Molecular Formula:
    5. Molecular Weight: 502.536
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1393127-04-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate(1393127-04-2)
    11. EPA Substance Registry System: ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate(1393127-04-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1393127-04-2(Hazardous Substances Data)

1393127-04-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1393127-04-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,3,1,2 and 7 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1393127-04:
(9*1)+(8*3)+(7*9)+(6*3)+(5*1)+(4*2)+(3*7)+(2*0)+(1*4)=152
152 % 10 = 2
So 1393127-04-2 is a valid CAS Registry Number.

1393127-04-2Relevant articles and documents

The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus

Guzman-Perez, Angel,Pfefferkorn, Jeffrey A.,Lee, Esther C.Y.,Stevens, Benjamin D.,Aspnes, Gary E.,Bian, Jianwei,Didiuk, Mary T.,Filipski, Kevin J.,Moore, Dianna,Perreault, Christian,Sammons, Matthew F.,Tu, Meihua,Brown, Janice,Atkinson, Karen,Litchfield, John,Tan, Beijing,Samas, Brian,Zavadoski, William J.,Salatto, Christopher T.,Treadway, Judith

, p. 3051 - 3058 (2013/06/27)

A novel and potent small molecule glucagon receptor antagonist for the treatment of diabetes mellitus is reported. This candidate, (S)-3-[4-(1-{3,5- dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy}butyl)benzamido] propanoic acid, has lower molecular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing. Additionally, it displays low in vivo clearance and excellent oral bioavailability in both rats and dogs. In a rat glucagon challenge model, it was shown to reduce the glucagon-elicited glucose excursion in a dose-dependent manner and at a concentration consistent with its rat in vitro potency. Its properties make it an excellent candidate for further investigation.

GLUCAGON RECEPTOR MODULATORS

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Page/Page column 97, (2012/08/27)

The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.

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