139336-65-5Relevant academic research and scientific papers
A facile cyclopropanol synthesis from β-halo ester with Grignard reagent-samarium(II) diiodide couple
Fukuzawa,Niimoto,Sakai
, p. 7691 - 7694 (1991)
Transformation of α,β-halo ester to the cyclopropanols by a coupled reagent of samarium(II) diiodide with Grignard reagent in tetrahydrofuran-hexamethylphosphoric triamide was very successful under mild conditions.
Iron-Catalyzed Ring-Opening Reactions of Cyclopropanols with Alkenes and TBHP: Synthesis of 5-Oxo Peroxides
Lou, Chenhao,Wang, Xin,Lv, Leiyang,Li, Zhiping
, p. 7608 - 7612 (2021/10/02)
The ring opening of cyclopropanols is rarely used in multicomponent reactions. Herein we report the three-component reaction of cyclopropanols with alkenes and tert-butyl hydroperoxide (TBHP) catalyzed by an iron catalyst. This protocol enables the incorporation of both the β-carbonyl fragment and a peroxy unit across the C=C double bond regioselectively, thus allowing an efficient, facile access to 5-oxo peroxides. Modification of the biologically active molecules and various downstream derivatizations of the peroxides are also demonstrated.
