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1394011-79-0

trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1394011-79-0 Structure

  • Basic information

    1. Product Name: trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester
    2. Synonyms: trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester
    3. CAS NO:1394011-79-0
    4. Molecular Formula:
    5. Molecular Weight: 513.944
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1394011-79-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester(1394011-79-0)
    11. EPA Substance Registry System: trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester(1394011-79-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1394011-79-0(Hazardous Substances Data)

1394011-79-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1394011-79-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,4,0,1 and 1 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1394011-79:
(9*1)+(8*3)+(7*9)+(6*4)+(5*0)+(4*1)+(3*1)+(2*7)+(1*9)=150
150 % 10 = 0
So 1394011-79-0 is a valid CAS Registry Number.

1394011-79-0Relevant articles and documents

Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors

Hwang, Sung Hee,Wecksler, Aaron T.,Zhang, Guodong,Morisseau, Christophe,Nguyen, Long V.,Fu, Samuel H.,Hammock, Bruce D.

, p. 3732 - 3737 (2013/07/27)

To reduce the pro-angiogenic effects of sEH inhibition, a structure-activity relationship (SAR) study was performed by incorporating structural features of the anti-angiogenic multi-kinase inhibitor sorafenib into soluble epoxide hydrolase (sEH) inhibitors. The structural modifications of this series of molecules enabled the altering of selectivity towards the pro-angiogenic kinases C-RAF and vascular endothelial growth factor receptor-2 (VEGFR-2), while retaining their sEH inhibition. As a result, sEH inhibitors with greater potency against C-RAF and VEGFR-2 were obtained. Compound 4 (t-CUPM) possesses inhibition potency higher than sorafenib towards sEH but similar against C-RAF and VEGFR-2. Compound 7 (t-CUCB) selectively inhibits sEH, while inhibiting HUVEC cell proliferation, a potential anti-angiogenic property, without liver cancer cell cytotoxicity. The data presented suggest a potential rational approach to control the angiogenic responses stemming from sEH inhibition.

SORAFENIB DERIVATIVES AS sEH INHIBITORS

-

, (2012/09/10)

The present invention provides compounds for the inhibition of soluble epoxide hydrolase and associated disease conditions.

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