139461-38-4

Upstream product

• 532-55-8 Benzoyl isothiocyanate 
• 107-11-9 1-amino-2-propene 
• 98-88-4 benzoyl chloride 
• 109-57-9 Allylthiourea 

Downstream Products

• 109-57-9 Allylthiourea 

Relevant academic research and scientific papers

ANTIVIRAL COMPOUNDS AND USE THEREOF

The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.

Docking, synthesis and cytotoxicity test on human breast cancer cell line (T47D) of N-(Allylcarbamothioyl)benzamide

We investigated a modification of the chemical structure in order to enhance the cytotoxicity test on human breast cancer cell lines. In this study, new compound had been found by reacting allylthiourea with benzoyl chloride. The molecular docking of this compound on EGFR (1M17.pdb) using MVD v5.5 showed that the Rerank Scores were lower than 5-fluorouracyl (5FU). It can be predicted that the compound has a higher biological activity. The synthesized of new compound N-(allylcarbamothioyl)benzamide (BATU) was performed through nucleophilic substitution mechanism of the Schotten Baumann method by using triethylamine as a base. The structure of the newly synthesized compound was confirmed by TLC, IR,1H NMR,13C NMR. The in vitro study of cytotoxicity test was evaluated on human breast cancer cell lines (T47D) using MTT assay. The result showed that this compound demonstrated more potent compared to 5-fluorouracil as the commercial anticancer drug, with respective IC50 were 56.5 μg/mL (BATU) and 132.4 μg/mL (5FU). It can be concluded that the synthesized compound can be further developed as a potential anticancer drug.

Straightforward Approach Toward Dihydrothiazoles via Intramolecular Bromocyclization

An intramolecular bromonium ion-assisted cyclization with sulfur as an internal nucleophile is described. Starting from benzoyl chlorides, this method provides an easy procedure for the synthesis of dihydrothiazole derivatives in moderate to good yields.

IMINE COMPOUND

An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl grou

A convenient and efficient method for the synthesis of mono- and N,N-disubstituted thioureas

A convenient method for the synthesis of mono- and N,N-disubstituted thioureas by the debenzoylation of N-substituted- and N,N-disubstituted- N′-benzoylthioureas with hydrazine hydrate under solvent-free conditions has been developed. N-Substituted-N′-benzoylthioureas and hydrazine hydrate were mixed, and stirred at room temperature without a solvent to give the corresponding N-substituted thioureas in high yields.

NG-Allyl- and NG-Cyclopropyl-L-arginine: Two Novel Inhibitors of Macrophage Nitric Oxide Synthase

NG-Methyl-L-arginine has recently been shown to inactivate the inducible murine macrophage nitric oxide (.NO) synthase (Olken, N.M.; Rusche, K.M.; Richards, M.K.; Marletta, M.A.Biochem.Biophys.Res.Commun. 1991, 177, 828-833).NG-Allyl-L-arginine and NG-cyclopropyl-L-arginine were synthesized as potential mechanism-based enzyme inhibitors to exploit the chemistry presumed to occur at the active site.NG-Cyclopropyl-L-arginine was found to be a potent reversible inhibitor with a Ki = 7.7 μM.NG-Allyl-L-arginine was found to be both a potent reversible (Ki = 2.1 μM) and irreversible inhibitor of the enzyme.The irreversible inhibition demonstrated pseudo-first-order inactivation kinetics with kinact = 0.026 min-1 and Ki = 3.4 μM.Stereospecific protection of the inactivation was afforded by L-arginine, and saturability of the inactivation rate was observed.Our studies indicate that both reversible and irreversible inhibition of the inducible .NO synthase can be achieved with relatively simple modifications of the substrate L-arginine.