1394837-17-2

Basic information

• Product Name: C₆₉H₁₁₄N₂₃O₁₉P
• CAS NO: 1394837-17-2
• Molecular Weight: 1600.78
• Mol File: 1394837-17-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₉H₁₁₄N₂₃O₁₉P(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₉H₁₁₄N₂₃O₁₉P(1394837-17-2)
• EPA Substance Registry System: C₆₉H₁₁₄N₂₃O₁₉P(1394837-17-2)

Safety Data

• Hazardous Substances Data: 1394837-17-2(Hazardous Substances Data)

Upstream product

• 1042937-12-1 C₉H₁₈NO₅P 
• 56-41-7 L-alanin 
• 63-91-2 L-phenylalanine 
• 71989-33-8 Fmoc-Ser(tBu)-OH 
• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 
• 71989-35-0 Fmoc-Thr(tBu)-OH 
• 56-40-6 glycine 
• 187618-60-6 Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine 

Relevant articles and documents

Synthesis and biological activity of new series of N-modified analogues of the N/OFQ(1-13)NH2 with aminophosphonate moiety

New series of N-modified analogues of the N/OFQ(1-13)NH2 with aminophosphonate moiety have been synthesized and investigated for biological activity. These peptides were prepared by solid-phase peptide synthesis-Fmoc-strategy. The N/OFQ(1-13)NH2 analogues were tested for agonistic activity in vitro on electrically stimulated rat vas deferens smooth-muscle preparations isolated from Wistar albino rats. Our study has shown that the selectivity of the peptides containing 1-[(methoxyphosphono) methylamino]cycloalkanecarboxylic acids to the N-side of Phe is not changed-they remain selective agonists of NOP receptors. The derivative with the largest ring (NOC-6) demonstrated efficacy similar to that of N/OFQ(1-13)NH2, but in a 10-fold higher concentration. The agonistic activity of newly synthesized N-modified analogues of N/OFQ(1-13)NH2 with aminophosphonate moiety was investigated for the first time.