139504-91-9

Upstream product

• 67-56-1 methanol 
• 137464-96-1 4-(4'-carboxyphenyl)-4-hydroxycyclohexanone ethylene ketal 
• 623-00-7 4-bromobenzenecarbonitrile 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 176208-23-4 methyl 4-<4-<(2-amino-4(3H)-oxopyrimidin-6-yl)hydrazono>-1-hydroxycyclohexyl>benzoate 
• 176208-26-7 diethyl N-<4-<2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl>benzoyl>-L-glutamate 
• 176208-24-5 methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate 
• 176208-25-6 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoic acid 
• 176208-17-6 methyl 4-<4-<(2-amino-4(3H)-oxopyrimidin-6-yl)hydrazono>cyclohexyl>benzoate 
• 176208-18-7 methyl 4-(2-amino-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate 
• 176208-19-8 4-(2-amino-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoic acid 
• 176208-16-5 4-(4-carbomethoxyphenyl)cyclohex-3-enone ethylene ketal 
• 885706-16-1 methyl 4-(1,4-dioxaspiro[4.5]decan-8-yl)benzoate 
• 137464-98-3 4-(4-oxocyclohexyl)benzoic acid methyl ester 
• 137464-97-2 4-(4'-carbomethoxyphenyl)-4-hydroxycyclohexanone ethylene ketal 

Relevant academic research and scientific papers

4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2

The present invention comprises compounds of Formula (I): wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

A fischer-indole approach to pyrrolo[2,3-d]pyrimidines

Several new 5,6-disubstituted pyrrolo[2,3-d]pyrimidines have been prepared by thermolysis of ketone hydrazones of 2-amino-6-hydrazino4(3H)-oxopyrimidine (8) (the Fischer-Indole Synthesis).