1395345-63-7

Upstream product

• 1395345-61-5 C₂₁H₃₄O₃Si 
• 688-73-3 tri-n-butyl-tin hydride 
• 1395345-59-1 C₁₅H₂₀O₃ 
• 1393364-40-3 tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methylpent-1-yn-3-yl)oxy)dimethylsilane 
• 1393364-39-0 tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane 
• 1393364-32-3 (3S,4S)-5-(4-methoxybenzyloxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-ol 
• 132969-60-9 (2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal 
• 136320-64-4 (2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol 
• 132969-71-2 methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 

Relevant academic research and scientific papers

Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes

An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities. The Royal Society of Chemistry 2013.