139610-52-9Relevant academic research and scientific papers
Synthesis of coenzyme A thioesters using methyl acyl phosphates in an aqueous medium
Pal, Mohan,Bearne, Stephen L.
, p. 9760 - 9763 (2014)
Regioselective S-acylation of coenzyme A (CoA) is achieved under aqueous conditions using various aliphatic and aromatic carboxylic acids activated as their methyl acyl phosphate monoesters. Unlike many hydrophobic activating groups, the anionic methyl acyl phosphate mixed anhydride is more compatible with aqueous solvents, making it useful for conducting acylation reactions in an aqueous medium.
Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S) - A potential mechanism for the anti-cancer effects of ibuprofen
Woodman, Timothy J.,Wood, Pauline J.,Thompson, Andrew S.,Hutchings, Thomas J.,Steel, Georgina R.,Jiao, Ping,Threadgill, Michael D.,Lloyd, Matthew D.
, p. 7332 - 7334 (2011/08/06)
Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs; 'profens'), such as ibuprofen, is important for pharmacological activity. Several 2-APA-CoA esters were good racemisation substrates for human AMACR 1A, suggesting a common chiral inversion pathway for all 2-APAs and an additional mechanism for their anti-cancer properties.
