139680-97-0Relevant academic research and scientific papers
Reaction of 2,2-Difluorovinyl Ketones with Heteroatom Nucleophiles: A General One-Pot Synthesis of α-Oxoketene Acetals
Ichikawa, Junji,Kobayashi, Masakuni,Yokota, Naoyuki,Noda, Yasuharu,Minami, Toru
, p. 11637 - 11646 (2007/10/02)
2,2-Difluorovinyl ketones readily react with heteroatom nucleophiles such as thiols, alcohols, and amines to undergo stepwise replacement of the two fluorine atoms via addition-elimination process.The reaction affords α-oxoketene acetals including S,S-, N
A one-pot synthesis of 2,2-difluorovinyl carbonyl compounds from 2,2,2-trifluoroethyl p-toluenesulfonate via 2,2-difluorovinylboranes
Ichikawa,Hamada,Sonoda,Kobayashi
, p. 337 - 340 (2007/10/02)
2,2,2-Trifluoroethyl p-toluenesulfonate is treated with butyllithium and trialkylboranes successively to generate 1-alkyl-2,2-difluorovinylboranes, which in turn react with acyl chlorides or chlorides or chloroformates in the presence of cuprous iodide to affort 2,2-difluorovinyl carbonyl compounds in good yields.
