70381-91-8

Upstream product

• 94454-57-6 3-(phenylmethoxy)-2-pyridinecarboxaldehyde 
• 6059-29-6 3-Benzyloxy-2-(hydroxymethyl)pyridine 
• 14047-53-1 3-hydroxy-2-hydroxymethylpyridine 
• 27066-72-4 ethyl 3-(5-ethoxyoxazol-4-yl)propanoate 
• 1549736-47-1 3-(5-ethoxyoxazol-4-yl)propan-1-ol 
• 79-10-7 acrylic acid 
• 139745-92-9 ethyl 3-(3-hydroxy-2-pyridinyl)propanoate 
• 139745-90-7 (E)-ethyl 3-(3-(benzyloxy)-2-pyridinyl)propenoate 

Downstream Products

• 70381-92-9 2,3-dihydro-4H-pyrano<3,2-b>pyridine 
• 1438073-62-1 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine 

Relevant academic research and scientific papers

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Metal-free decarboxylative Hetero-Diels-Alder synthesis of 3-hydroxypyridines: A rapid access to N-fused bicyclic hydroxypiperidine scaffolds

A complete experimental and theoretical study of the thermally controlled metal-free decarboxylative hetero-Diels-Alder (HDA) reaction of 5-alkoxyoxazoles with acrylic acid is reported. This strategy offers a new entry to valuable 2,6-difunctionalized 3-hydroxypyridines from readily available 2- and 4-disubstituted 5-alkoxyoxazoles. The reaction conditions proved compatible with, among others, ketone, amide, ester, ether, and nitrile groups. The broad functional group tolerance of the protocol allows a rapid and versatile access to both hydroxyindolizidine and hydroxyquinolizidine derivatives via a pyridine dearomatization strategy.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.