139759-75-4Relevant academic research and scientific papers
Palladium-catalyzed C-H activation of simple arenes and cascade reaction with nitriles: access to 2,4,5-trisubstituted oxazoles
Dai, Ling,Yu, Shuling,Shao, Yinlin,Li, Renhao,Chen, Zhongyan,Lv, Ningning,Chen, Jiuxi
, p. 1376 - 1379 (2021)
An efficient and straightforward protocol for the assembly of the pharmaceutically and biologically valuable oxazole skeleton is achieved for the first time from readily available simple arenes and functionalized aliphatic nitriles. This transformation in
Synthesis method of 2, 4, 5-trisubstituted oxazole compound
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Paragraph 0036-0044; 0070-0072, (2021/06/23)
The invention discloses a simple and efficient synthesis method of a 2, 4, 5-trisubstituted oxazole compound, which comprises the following steps: adding a cyano-substituted ester compound, simple aromatic hydrocarbon, palladium acetylacetonate and dimeth
Titanium enolate radical cations in solution: generation, characterization, and their reactions
Schmittel, Michael,Soellner, Rolf
, p. 771 - 777 (2007/10/03)
For the first time, titanium enolate radical cations were characterized in cyclic voltammetry experiments. Preparative one-electron oxidation of titanium enolates 1-3 led to the formation of benzofurans B1-B3 through mesolytic Ti-O bond fragmentation to α-carbonyl radical and a cationic titanocene(IV) species. With 1+, the kinetics of the Ti-O bond cleavage was investigated by fast scan cyclic voltammetry providing a first-order rate constant kf = 850 ± 50 s-1 in acetonitrile at room temperature. The titanium enolate radical cations 1+, 3+, 4+ and 5+ were characterized by EPR spectroscopy, qualifying these species as electrophilic radicals. This feature can be exploited in C-C bond formation reactions such as the formal dimerization of 6 to 2,3-dimethyl1,4-diphenylbuta-1,4-dione D6, which takes place on stage of the radical cation 6+. VCH Verlagsgesellschaft mbH.
Reaction of Enol Cation Radicals in the Presence of Nucleophiles
Schmittel, Michael,Roeck, Maik
, p. 1611 - 1620 (2007/10/02)
The one-electron oxidation chemistry of three diaryl-substituted enols, 1,1-dimesityl-1-propen-2-ol (7), 1,2-dimesityl-1-propen-1-ol (8), and 2-mesityl-2-phenylethenol (9), has been examined.As a consequence of the pronounced steric shielding around the β
