139893-48-4

Upstream product

• 127696-10-0 trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester 
• 100-39-0 benzyl bromide 
• 126261-70-9 (+/-)-trans-1,2-bis-(3,3-diethoxycyclobutylen)methanol 
• 161395-11-5 cis-3,4-bis(benzyloxymethyl)cyclobut-1-ene 
• 139744-48-2 trans-3,3-diethoxy-1,2-bis<(benzyloxy)methyl>cyclobutane 

Downstream Products

• 142434-69-3 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutanol 
• 142343-73-5 (-)-(1R,2R,3R)-2,3-bis<(benzyloxy)methyl>-1-cyclobutanol 
• 142343-78-0 (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one 
• 142343-77-9 (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine 
• 142343-74-6 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutyl tosylate 
• 142343-75-7 C₂₀H₂₃N₃O₂ 
• 142343-72-4 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutyl acetate 
• 142343-76-8 (+)-(1R,2S,3S)-2,3-bis<(benzyloxy)methyl>cyclobutylamine 
• 142343-73-5 (+/-)-(1α,2α,3β)-2,3-bis<(benzyloxy)methyl>cyclobutanol 

Relevant academic research and scientific papers

Synthesis of a novel trisubstituted cyclobutane nucleoside analogue. Unexpected C4-C3 ring contractions in related reactions

Nucleoside analogue 7 was obtained by nuclceophilic substitution between adenine and mesylate 5b. On the other hand the same reaction starting from its isomer 5a did not work and led to the surprising ring contraction products 8a and 8b. Another unexpected ring contraction leading to 15 was pointed out in the course of preparation of the deuteriated compounds 5a' and 5a''. Position of deuterium in products 8a' and 8b' or 8a'' and 8b'' issued from reactions with 5a' or 5a'' gave useful mechanistic informations on this reaction.

CYCLOBUTYL NUCLEOSIDE ANALOGS AS ANTI-VIRALS

Described herein are cyclobutyl nucleoside analogs of Formula (I), pharmaceutical compositions that include one or more cyclobutyl nucleoside analogs and methods of using the same to treat HBV, HDV and/or HIV.

Synthetic studies toward providencin: Efficient construction of a furanyl-cyclobutanone fragment

Described is the construction of a furanyl-cylcobutanone fragment suited for incorporation into a synthesis of the naturally occurring anti-cancer agent Providencin.

CHEMOENZYMATIC SYNTHESIS OF (-)-CARBOCYCLIC 7-DEAZAOXETANOCIN G

The enantioselective synthesis of (-)-(1R,2S,3S)-2-amino-7-pyrrolopyrimidin-4(3H)-one (5) as the 7-deaza analogue of carbocyclic oxetanocin G is described in 13 steps from trans-3,3-diethoxy-1,2-bis(hydroxymethyl)c