139744-48-2

Upstream product

• 100-39-0 benzyl bromide 
• 126261-70-9 (+/-)-trans-1,2-bis-(3,3-diethoxycyclobutylen)methanol 
• 2678-54-8 ketene diethyl acetal 
• 127696-10-0 trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester 

Downstream Products

• 142343-73-5 (+/-)-(1α,2α,3β)-2,3-bis<(benzyloxy)methyl>cyclobutanol 
• 142434-69-3 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutanol 
• 142343-73-5 (-)-(1R,2R,3R)-2,3-bis<(benzyloxy)methyl>-1-cyclobutanol 
• 142343-78-0 (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one 
• 142343-77-9 (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine 
• 142343-74-6 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutyl tosylate 
• 142343-75-7 C₂₀H₂₃N₃O₂ 
• 142343-72-4 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutyl acetate 
• 142343-76-8 (+)-(1R,2S,3S)-2,3-bis<(benzyloxy)methyl>cyclobutylamine 
• 132164-72-8 trans-2,3-bis<(benzyloxy)methyl>cyclobutanone 

Relevant academic research and scientific papers

Synthetic studies toward providencin: Efficient construction of a furanyl-cyclobutanone fragment

Described is the construction of a furanyl-cylcobutanone fragment suited for incorporation into a synthesis of the naturally occurring anti-cancer agent Providencin.

CYCLOBUTYL NUCLEOSIDE ANALOGS AS ANTI-VIRALS

Described herein are cyclobutyl nucleoside analogs of Formula (I), pharmaceutical compositions that include one or more cyclobutyl nucleoside analogs and methods of using the same to treat HBV, HDV and/or HIV.

CHEMOENZYMATIC SYNTHESIS OF (-)-CARBOCYCLIC 7-DEAZAOXETANOCIN G

The enantioselective synthesis of (-)-(1R,2S,3S)-2-amino-7-pyrrolopyrimidin-4(3H)-one (5) as the 7-deaza analogue of carbocyclic oxetanocin G is described in 13 steps from trans-3,3-diethoxy-1,2-bis(hydroxymethyl)c