139926-13-9Relevant academic research and scientific papers
XANOMELINE DERIVATIVES AND METHODS FOR TREATING NEUROLOGICAL DISORDERS
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Paragraph 0216; 0218-0219, (2021/05/21)
Provided herein are compounds comprising compounds of formula (I) and/or salts thereof; wherein at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine, and the remainder are independently chosen from hydrogen and fluorine; and R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23 are independently chosen from hydrogen and deuterium; with the proviso that when R1, R2, and R3 are fluorine, then at least one of R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine or at least one of R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23is deuterium. Also provided are medicaments comprising these compounds and methods for treating central nervous system disorders with the compounds and medicaments described herein.
One-pot cascade synthesis of azabicycles via the nitro-Mannich reaction and N -alkylation
Disadee, Wannaporn,Ruchirawat, Somsak
supporting information, p. 707 - 711 (2018/02/09)
A one-pot, metal-free process for the synthesis of azabicycles is developed. The key transformations involved a cascade of double intramolecular cyclizations via the nitro-Mannich reaction and N-alkylation, providing various ring systems of azabicycles in
First stereoselective total synthesis of naturally occurring (6 R)-6-(4-Oxopentyl)-5,6-dihydro-2 H -pyran-2-one and Its (6 S)-enantiomer
Shinde, Digambar Balaji,Kanth, Boddu Shashi,Srilatha, Malampati,Das, Biswanath
, p. 469 - 473 (2012/03/26)
(6R)-6-(4-Oxopentyl)-5,6-dihydro-2H-pyran-2-one, a naturally occurring ,-unsaturated -lactone, and its (6S)-enantiomer have been synthesized stereoselectively starting from pentane-1,5-diol. The synthesis involves Maruoka asymmetric allylation and ring-cl
Chemoselective reduction of aldehydes over ketones with sodium tris(hexafluoroisopropoxy)borohydride
Kuroiwa, Yasutaka,Matsumura, Shuichi,Toshima, Kazunobu
body text, p. 2523 - 2525 (2009/04/16)
Chemoselective reduction of aldehydes in the presence of ketones was achieved using sodium tris(hexafluoroisopropoxy)borohydride which can be stored as a THF solution. Georg Thieme Verlag Stuttgart.
Regioselective Reduction of 2,3-Epoxy Alcohol Derivatives. An Efficient Route to Enantiomerically Pure 2-Alkanols
Chong, J. Michael
, p. 33 - 36 (2007/10/02)
Reduction of 2,3-epoxy tosylates with DIBAL-H provides high yields of 2-alkanols. Key words: 2,3-epoxy tosylate; regioselective reduction; enantiomerically pure; 2-alkanol
