99701-65-2Relevant academic research and scientific papers
Novel functional group transformation from acetylene cobalt complex to ketone via ligand exchange
Hamajima, Akinari,Nakata, Hiyoku,Goto, Masako,Isobe, Minoru
, p. 464 - 465 (2006)
A new transformation of acetylene dicobalt tetracarbonyl dppm complexes was found to convert to ketones with high regioselectivity under ligand exchange condition. Copyright
XANOMELINE DERIVATIVES AND METHODS FOR TREATING NEUROLOGICAL DISORDERS
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Paragraph 0216; 0220, (2021/05/21)
Provided herein are compounds comprising compounds of formula (I) and/or salts thereof; wherein at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine, and the remainder are independently chosen from hydrogen and fluorine; and R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23 are independently chosen from hydrogen and deuterium; with the proviso that when R1, R2, and R3 are fluorine, then at least one of R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine or at least one of R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23is deuterium. Also provided are medicaments comprising these compounds and methods for treating central nervous system disorders with the compounds and medicaments described herein.
Palladium-Catalyzed Aerobic Anti-Markovnikov Oxidation of Aliphatic Alkenes to Terminal Acetals
Komori, Saki,Yamaguchi, Yoshiko,Kataoka, Yasutaka,Ura, Yasuyuki
, p. 3093 - 3099 (2019/03/29)
Terminal acetals were selectively synthesized from various unbiased aliphatic terminal alkenes and 1,2-, 1,3-, or 1,4-diols using a PdCl2(MeCN)2/CuCl catalyst system in the presence of p-toluquinone under 1 atm of O2 and mild reaction conditions. The slow addition of terminal alkenes suppressed the isomerization to internal alkenes successfully. Electron-deficient cyclic alkenes, such as p-toluquinone, were key additives to enhance the catalytic activity and the anti-Markovnikov selectivity. The halogen groups in the alkenes were found to operate as directing groups, suppressing isomerization and increasing the selectivity efficiently.
2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS
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, (2017/02/09)
The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.
Multicatalytic processes using diverse transition metals for the synthesis of alkenes
Lebel, Helene,Paquet, Valrie
, p. 11152 - 11153 (2007/10/03)
A series of cascade processes for the synthesis of alkenes from alcohols is described. Each individual step is catalyzed with a specific transition metal complex. The oxidation-methylenation one-pot procedure took place in the presence of a palladium and a rhodium catalyst to produce the desired terminal alkenes in high yields. A methylenation-ring-closing metathesis allowed the synthesis of cyclic alkenes from carbonyl derivatives, using the second-generation metathesis catalyst. Finally, an oxidation-methylenation-RCM process that involves up to three different transition metal catalysts in the same vessel is presented. Copyright
Mercuric triflate-TMU catalyzed hydration of terminal alkyne to give methyl ketone under mild conditions
Nishizawa, Mugio,Skwarczynski, Mariusz,Imagawa, Hiroshi,Sugihara, Takumichi
, p. 12 - 13 (2007/10/03)
Herein developed mercuric triflate-TMU catalyzed hydration of terminal alkyne is a mild procedure to give methyl ketone in excellent yield with high chemoselectivity. By using 0.05 eq of Hg(OTf)2·(TMU)2 and 3 eq of water, hydration takes place at a reasonable rate in acetonitrile.
Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization
Hasserodt, Jens,Janda, Kim D.,Lerner, Richard A.
, p. 5993 - 5998 (2007/10/03)
We report the antibody catalysis of an electrophilic tandem ring forming process that yields a bicyclic ring system at neutral pH. Three closely related decalin systems that represent rings A and B of the steroid nucleus account for 50% of the overall pro
O-Glycosyl Imidates, 19. - Reactions of Glycosyl Trichloroacetimidates with Silylated C-Nucleophiles
Hoffmann, Michael G.,Schmidt, Richard R.
, p. 2403 - 2419 (2007/10/02)
Reaction of O-benzyl-protected α-glycopyranosyl trichloroacetimidates 1 and the xylo analogues 7 with silyl enol ethers or allyltrimethylsilane as C-nucleophiles yields with zink chloride as catalyst mainly or exclusively α-C-glycosides (5a-α to 5h-α, 8b,
