14001-60-6

Basic information

• Product Name: 2-Methoxy-4-methylpyrimidine
• Synonyms: 2-METHOXY-4-METHYLPYRIMIDINE;Pyrimidine, 2-methoxy-4-methyl- (8CI,9CI)
• CAS NO: 14001-60-6
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• Product Categories: PYRIMIDINE;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides
• Mol File: 14001-60-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 108-110C/70mmHg
• Flash Point: 77.2 °C
• Appearance: Colourless Liquid
• Density: 1.068 g/cm³
• Vapor Pressure: 0.241mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ether, Ethyl Acetate, Methanol
• PKA: 1.69±0.20(Predicted)
• CAS DataBase Reference: 2-Methoxy-4-methylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-4-methylpyrimidine(14001-60-6)
• EPA Substance Registry System: 2-Methoxy-4-methylpyrimidine(14001-60-6)

Safety Data

• Hazardous Substances Data: 14001-60-6(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Liquid

Uses

2-Methoxy-4-methylpyrimidine (cas# 14001-60-6) is a compound useful in organic synthesis.

InChI:InChI=1/C6H8N2O/c1-5-3-4-7-6(8-5)9-2/h3-4H,1-2H3

Upstream product

• 13036-57-2 2-chloro-4-methylpyrimidine 
• 124-41-4 sodium methylate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 67-56-1 methanol 
• 5348-51-6 2-hydroxy-4-methylpyrimidine hydrochloride 
• 56681-97-1 4,4-dimethoxybutanal 
• 2440-60-0 2-methyl-isourea 

Downstream Products

• 74195-37-2 2-Methoxy-4-(4-bromophenacyl)pyrimidine 
• 1181759-42-1 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-N-(2-methoxy-pyrimidin-4-ylmethyl)-3-methyl-benzenesulfonamide 
• 944901-04-6 C-(2-methoxy-pyrimidin-4-yl)-methylamine 
• 74195-36-1 4-<(4-Bromobenzoyl)methenyl>-5,6-dihydro-2(1H)-pyrimidinone 

Relevant articles and documents

One-pot etherification of purine nucleosides and pyrimidines

A one-pot synthesis of ethers derived from inosine, guanosine, 2′-deoxyguanosine, and pyrimidinones is described. Exposure of the heterocycle to 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and Cs2CO3/s

Study on the preparation of heteroaryl substituted enamines. A simple synthesis of heteroaryl substituted acetaldoximes from enamines

A comparative study of the reactivity of methyl groups towards N,N-dimethylformamide dimethyl acetal and tert-butoxybis(dimethylamino)methane was carried out on methyl substituted six-membered nitrogen containing heterocycles 1 to give enamines 2, which were easily transformed to oximes by treating with hydroxylamine hydrochloride in methanol. Most of them were isolated as (E,Z)-oximes of heteroarylacetaldehyde (11), but 5-(1,2,4-triazinyl) substituted derivatives as (E,Z)-oximes of 2,5-dihydro-1,2,4-triazin-(Z)-5-ylideneacetaldehyde (11t, 11u, and 12). Oximes were finally transformed to the corresponding acetonitriles 16 and 3-(dimethylamino)acrylonitriles 17.