14001-69-5

Usage

Uses

Used in Biochemical Research:
2-methoxy-5-nitropyrimidine is used as a research compound for its structural similarities to bioactive molecules, which allows for the investigation of its potential interactions and effects within biological systems.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-methoxy-5-nitropyrimidine is used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its unique structure and properties make it a valuable component in the development of new drugs and therapeutic agents.

InChI:InChI=1/C5H5N3O3/c1-11-5-6-2-4(3-7-5)8(9)10/h2-3H,1H3

Upstream product

• 64-17-5 ethanol 
• 74-88-4 methyl iodide 
• 5329-33-9 o-methylisourea hydrochloride 
• 14080-32-1 5-nitropyrimidine 
• 628692-15-9 (2-methoxypyrimidin-5-yl)boronic acid 
• 10320-42-0 2-Chloro-5-nitropyrimidine 
• 124-41-4 sodium methylate 

Downstream Products

• 13207-98-2 2-Aethoxy-5-nitro-pyrimidin 
• 1450-76-6 1-(2-hydroxy-5-nitrophenyl)ethanone 
• 56621-89-7 5-amino-2-methoxypyrimidine 

Relevant academic research and scientific papers

N-Nitroheterocycles: Bench-Stable Organic Reagents for Catalytic Ipso-Nitration of Aryl- And Heteroarylboronic Acids

Photocatalytic and metal-free protocols to access various aromatic and heteroaromatic nitro compounds through ipso-nitration of readily available boronic acid derivatives were developed using non-metal-based, bench-stable, and recyclable nitrating reagents. These methods are operationally simple, mild, regioselective, and possess excellent functional group compatibility, delivering desired products in up to 99% yield.

PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY

Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazoles of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.

COMPOUNDS AND THERAPEUTICAL USE THEREOF

Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Ring Transformations in Reactions of Heterocyclic Compounds with Nucleophiles. Conversion of 5-Nitropyrimidine into 2-Substituted 5-Nitropyrimidine and 2-Amino-5-nitropyridines by Amidines

The reaction of 5-nitropyrimidine (1) with benzamidine, pivalamidine, acetamidine, propionamidine, α-phenylacetamidine, O-methylisourea hydrochlorides, and cyanamide in ethanolic solution in the presence of triethylamine has been investigated.It was found that reaction of 1 with alkyl(aryl) amidines, having no active methylene groups attached to the amidine moiety (pivalamidine, benzamidine), exclusively formed the corresponding 2-substituted 5-nitropyrimidines in good yields.With acetamidine and propionamidine, in addition to the formation of the 2-substituted 5-nitropyrimidines, the formation of 2-amino-5-nitropyridines also was observed; with α-phenylacetamidine a 2-amino-5-nitropyridine derivative exclusively was obtained.The reaction of 1 with both O-methylisourea and cyanamide leads to 2-amino-5-nitropyrimidine.These reactions provide new examples of degenerate ring transformations of the pyrimidine ring system and of the ring transformation of pyrimidines into pyridines.