14005-50-6Relevant articles and documents
A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation
Pandya, Amit N.,Villa, Eric M.,North, E. Jeffrey
, p. 1276 - 1279 (2017)
A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for scale up synthesis and ligand diversity. Notably, this methodology allows for the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy.
Synthesis of 2-Aminoquinazolines from ortho-Fluoroketones
Hynes, John B.,Campbell, Johnny P.,Hynes, John D.
, p. 1185 - 1188 (2007/10/02)
The reactions of ten ortho-fluoroketones with guanidine carbonate in N,N-dimethylacetamide were investigated as a new synthetic approach to 2-amino-4-alkyl- and 2-amino-4-arylquinazolines.The yields obtained ranged from low to moderate and were highly dep
