1400902-26-2Relevant articles and documents
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
Hunt, Hazel J.,Ray, Nicholas C.,Hynd, George,Sutton, Jon,Sajad, Mohammed,O'Connor, Elizabeth,Ahmed, Shahadat,Lockey, Peter,Daly, Steve,Buckley, Gerry,Clark, Robin D.,Roe, Robert,Blasey, Christine,Belanoff, Joe
, p. 7376 - 7380 (2012)
We report the optimization of a series of non-steroidal GR antagonists that led to the identification of compound 7. This compound is efficacious when dosed orally in an olanzapine-induced weight gain model in rats.
PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS
-
Page/Page column 32, (2012/10/08)
The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators