Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat

DOI: 10.1016/j.bmcl.2012.10.074

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 7376 - 7380 (2012)

Update date:2022-07-29

Topics:

Authors:

Hunt, Hazel J.

Ray, Nicholas C.

Hynd, George

Sutton, Jon

Sajad, Mohammed

O'Connor, Elizabeth

Ahmed, Shahadat

Lockey, Peter

Daly, Steve

Buckley, Gerry

Clark, Robin D.

Roe, Robert

Blasey, Christine

Belanoff, Joe

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Article abstract of DOI:10.1016/j.bmcl.2012.10.074

We report the optimization of a series of non-steroidal GR antagonists that led to the identification of compound 7. This compound is efficacious when dosed orally in an olanzapine-induced weight gain model in rats.

Full text of DOI:10.1016/j.bmcl.2012.10.074

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