1401070-41-4

Upstream product

• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 2054-14-0 α-(4-fluorophenyl)-4-fluorobenzeneacetaldehyde 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 
• 83948-53-2 3-bromopropylamine tert-butylcarbamate 

Downstream Products

• 610319-10-3 [3-(3-amino-propoxy)-phenyl]-acetic acid methyl ester hydrochloride 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME

Disclosed is a compound of having the formula (II-A), pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.