2054-14-0Relevant articles and documents
Construction of Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 3-Arylpiperidin-2-ones Under Phase-Transfer Conditions
Inukai, Tomoaki,Kano, Taichi,Maruoka, Keiji
supporting information, p. 2211 - 2214 (2020/01/08)
A highly enantioselective synthesis of δ-lactams having a chiral quaternary carbon center at the α-position has been developed through an asymmetric alkylation of 3-arylpiperidin-2-ones under phase-transfer conditions. In this transformation, a 2,2-diarylvinyl group on the δ-lactam nitrogen atom plays a crucial role as a novel protecting group and an achiral auxiliary for improving both yield and enantioselectivity of the reaction.
Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncology
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Page 30, (2010/02/08)
The present invention relates to novel compounds derived from indazoles or indoles of formula (1) or formula (2), to methods for treating tumors or cancerous cells with compounds of formula (1) or formula (2) and to pharmacaetutical compositions comprisin
ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME
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Page/Page column 35; 61-62, (2008/06/13)
Disclosed is a compound of having the formula (II-A), pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.