1402559-21-0

Basic information

• Product Name: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate
• Synonyms: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate;Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate(WXC01007)
• CAS NO: 1402559-21-0
• Molecular Formula: C₁₁H₁₅FN₂O₂
• Molecular Weight: 226.2474032
• Mol File: 1402559-21-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate(1402559-21-0)
• EPA Substance Registry System: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate(1402559-21-0)

Safety Data

• Hazardous Substances Data: 1402559-21-0(Hazardous Substances Data)

Usage

General Description

Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate is a chemical compound with the formula C11H15FN2O2. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active compounds. Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate is a carbamate derivative containing a tert-butyl group, amino group, and fluorophenyl group, which make it useful for modifying the properties of molecules in drug development. Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate has potential applications in the field of medicinal chemistry for the design and development of new pharmaceutical agents with improved pharmacological properties.

Upstream product

• 2369-13-3 3-fluoro-4-nitroaniline 
• 658700-15-3 tert-butyl N-(3-fluoro-4-nitrophenyl)carbamate 
• 220913-42-8 tert-butyl (2-fluoro-4-nitrophenyl)carbamate 
• 369-35-7 2-fluoro-4-nitroaniline 

Downstream Products

• 1402559-22-1 tert-butyl N-[4-(benzyloxycarbonylamino)-3-fluorophenyl]carbamate 
• 1402559-13-0 C₁₄H₁₃FN₂O₂ 
• 1402559-23-2 benzyl N-[4-(cyanomethylamino)-2-fluorophenyl]carbamate 
• 1402559-14-1 benzyl N-[4-[(2-cyanocyclopenten-1-yl)-(cyanomethyl)amino]-2-fluorophenyl]carbamate 
• 1402559-15-2 benzyl N-[4-(3-amino-2-cyano-5,6-dihydro-4H-cyclopenta[b]pyrrol-1-yl)-2-fluorophenyl]carbamate 
• 1402558-99-9 5-(4-amino-3-fluorophenyl)-7,8-dihydro-6H-cyclopenta[2,3]pyrrolo[2,4-d]pyrimidin-4-amine 
• 1402558-98-8 benzyl N-[4-(4-amino-7,8-dihydro-6H-cyclopenta[2,3]pyrrolo[2,4-d]pyrimidin-5-yl)-2-fluorophenyl]carbamate 

Relevant articles and documents

Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer

A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) therapy. Structure-activity relationship analysis based on enzymatic and cellular activities led to the discovery of a promising inhibitor 21e. 21e potently inhibited CDK9 with IC50 value of 11 nM and suppressed the stemness properties of NSCLC effectively. It could decrease the stemness phenotypes of NSCLC cells, including tumor sphere formation, side-population and stemness markers abundance. 21e displayed good selectivity over the CDK family kinases and kinase profiling assay against 381 kinases. In addition, 21e inhibited cell proliferation, colony-formation, and cell cycle progression and induced apoptosis in NSCLC. In H1299 xenograft mouse model, a once-daily dose of compound 21e at 20 mg/kg significantly suppressed the tumor growth without obvious toxicity. Studies of mechanisms of action indicated that 21e efficiently inhibited CDK9 signaling pathway and stemness both in vitro and in vivo. Collectively, 21e as a novel CDK9 inhibitor with CSCs inhibition properties could be a promising agent for the treatment of NSCLC.

PROTEIN KINASE INHIBITORS

The present invention relates to novel kinase inhibitors. Compounds of this class have been found to be effective inhibitors of protein kinases; including members of PDGFR and VEGFR families.