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Carbamic acid, (3-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 658700-15-3 Structure
  • Basic information

    1. Product Name: Carbamic acid, (3-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester
    2. Synonyms:
    3. CAS NO:658700-15-3
    4. Molecular Formula: C11H13FN2O4
    5. Molecular Weight: 256.234
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 658700-15-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Carbamic acid, (3-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: Carbamic acid, (3-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester(658700-15-3)
    11. EPA Substance Registry System: Carbamic acid, (3-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester(658700-15-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 658700-15-3(Hazardous Substances Data)

658700-15-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 658700-15-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,8,7,0 and 0 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 658700-15:
(8*6)+(7*5)+(6*8)+(5*7)+(4*0)+(3*0)+(2*1)+(1*5)=173
173 % 10 = 3
So 658700-15-3 is a valid CAS Registry Number.

658700-15-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (3-fluoro-4-nitrophenyl)carbamic acid tert-butyl ester

1.2 Other means of identification

Product number -
Other names (tert-butoxy)-N-(3-fluoro-4-nitrophenyl)carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:658700-15-3 SDS

658700-15-3Relevant articles and documents

Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer

Wang, Xin,Yu, Chenhua,Wang, Cheng,Ma, Yakun,Wang, Tianqi,Li, Yao,Huang, Zhi,Zhou, Manqian,Sun, Peiqing,Zheng, Jianyu,Yang, Shengyong,Fan, Yan,Xiang, Rong

supporting information, (2019/08/02)

A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) therapy. Structure-activity relationship analysis based on enzymatic and cellular activities led to the discovery of a promising inhibitor 21e. 21e potently inhibited CDK9 with IC50 value of 11 nM and suppressed the stemness properties of NSCLC effectively. It could decrease the stemness phenotypes of NSCLC cells, including tumor sphere formation, side-population and stemness markers abundance. 21e displayed good selectivity over the CDK family kinases and kinase profiling assay against 381 kinases. In addition, 21e inhibited cell proliferation, colony-formation, and cell cycle progression and induced apoptosis in NSCLC. In H1299 xenograft mouse model, a once-daily dose of compound 21e at 20 mg/kg significantly suppressed the tumor growth without obvious toxicity. Studies of mechanisms of action indicated that 21e efficiently inhibited CDK9 signaling pathway and stemness both in vitro and in vivo. Collectively, 21e as a novel CDK9 inhibitor with CSCs inhibition properties could be a promising agent for the treatment of NSCLC.

COMPOUNDS USEFUL AS CSF1 MODULATORS

-

Paragraph 00230; 00231; 00232, (2016/04/26)

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO

-

Page/Page column 407-408, (2016/10/31)

This disclosure relates to the field of moiecuies having pesticida i utility against pests in Phyla Arthropoda, Moliusca, and hJematoda, processes to produce such moiecuies, intermediates used In such processes, pesticidai compositions containing such molecules, and processes of using such pesticidai compositions against such pests. These pesticidai compositions may be used, for example, as acaricldes, insecticides, miticides, moilusclcides, and nematicides. This document discloses moiecuies having the following formula ("Formula One").

PROTEIN KINASE INHIBITORS

-

Page/Page column 51-52, (2012/10/18)

The present invention relates to novel kinase inhibitors. Compounds of this class have been found to be effective inhibitors of protein kinases; including members of PDGFR and VEGFR families.

ARYL GUANIDINE F1F0-ATPASE INHIBITORS AND RELATED METHODS

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Page/Page column 59-60, (2010/04/06)

The invention provides to a family of aryl guanidine-based F1F0-ATPase inhibitors, e.g., mitochondrial F1F0-ATPase inhibitors, methods for their discovery, and their use as therapeutic agents for treating certai

Identification and hit-to-lead optimization of a novel class of CB1 antagonists

Letourneau, Jeffrey J.,Jokiel, Patrick,Olson, John,Riviello, Christopher M.,Ho, Koc-Kan,McAleer, Lihong,Yang, Jingchun,Swanson, Robert N.,Baker, James,Cowley, Phillip,Edwards, Darren,Ward, Nick,Ohlmeyer, Michael H.J.,Webb, Maria L.

scheme or table, p. 5449 - 5453 (2011/01/03)

The discovery, synthesis and preliminary structure-activity relationships (SARs) of a novel class of CB1 antagonists is described. Initial optimization of benzimidazole-based screening hit 4 led to the identification of 'inverted' indole-based lead compound 18c with improved properties versus compound 4 including reduced A log P, improved microsomal stability and improved aqueous solubility. Compound 18c demonstrates in vivo CB1 antagonist efficacy (CB1 agonist induced hypothermia model) and is orally bioavailable in rat.

SUBSTITUTED BENZIMIDAZOLE COMPOUNDS

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Page 157-158, (2008/06/13)

Disclosed are substituted benzimidazole compounds of formula (I) wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and the pharmaceutical compositions comprising these compounds.

2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY

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Page/Page column 6, (2008/06/13)

The subject invention relates to compounds having the structure: (I) wherein: (a) R1 is selected from the group consisting of alkyl, aryl, alkoxy, and aryloxy, the alkyl and aryl portions of preferred R1 having from 1 to about 14 carbon atoms; (b) R3 and R4 are independently selected from the group consisting of hydrogen, halo, alkyl, alkoxy, alkyl-aryloxy, alkylthio, amino, and mono- or dialkylaminio, the alkyl portions of preferred R3 and R4 having from 1 to about 8 carbon atoms; except that R3 and R4 are not both hydrogen; (c) each R5 is independently selected from the group consisting of hydrogen, halo, cyano, alkyl, hydroxy, alkoxy, thio, alkylthio, amino, and mono- or dialkylamino, the alkyl portions of preferred R5 having from 1 to about 8 carbon atoms. The subject invention further relates to compositions comprising these compound. The subject compounds are useful for preventing or treating reperfusion injury of a variety of tissues.

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