1403605-22-0

Basic information

• Product Name: C₂₂H₂₃BrN₂O₄
• Synonyms: C₂₂H₂₃BrN₂O₄
• CAS NO: 1403605-22-0
• Molecular Weight: 459.34
• Mol File: 1403605-22-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₃BrN₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₃BrN₂O₄(1403605-22-0)
• EPA Substance Registry System: C₂₂H₂₃BrN₂O₄(1403605-22-0)

Safety Data

• Hazardous Substances Data: 1403605-22-0(Hazardous Substances Data)

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 25070-74-0 1-benzyloxycarbonylpyrrolidine 
• 106-40-1 4-bromo-aniline 
• 915712-34-4 (4-bromo-phenylimino)-acetic acid ethyl ester 
• 68471-57-8 2,3-dihydro-pyrrole-1-carboxylic acid benzyl ester 

Relevant articles and documents

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A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques. A tetrahydroquinoline (THQ) scaffold was prepared via an asymmetric Povarov reaction using cooperative catalysis to generate three contiguous stereogenic centers. A matrix of 4 stereoisomers of the THQ scaffold was prepared to enable the development of stereo/structure-activity relationships (SSAR) upon biological testing. A sparse matrix design strategy was employed to select library members to be synthesized with the goal of generating a diverse collection of tetrahydroquinolines with physicochemical properties suitable for downstream discovery.