140413-11-2

Usage

InChI:InChI=1/C13H10N2O2/c1-8-4-5-10-11(7-8)17-13-9(12(16)15-10)3-2-6-14-13/h2-7H,1H3,(H,15,16)

Upstream product

• 140413-43-0 2-Chloro-N-(2-hydroxy-4-methyl-phenyl)-nicotinamide 
• 52200-48-3 3-bromo-2-chloropyridine 
• 15226-74-1 dicobalt octacarbonyl 
• 2835-98-5 2-Hydroxy-4-methylanilin 
• 36178-05-9 3-bromo-2-fluoropyridine 
• 201230-82-2 carbon monoxide 
• 49609-84-9 2-Chloronicotinoyl chloride 

Downstream Products

• 140413-25-8 10-Ethyl-7-methyl-9-nitro-10H-5-oxa-4,10-diaza-dibenzo[a,d]cyclohepten-11-one 
• 140413-36-1 9-Methanesulfonyl-7,10-dimethyl-10H-5-oxa-4,10-diaza-dibenzo[a,d]cyclohepten-11-one 
• 140413-27-0 10-Ethyl-7-methyl-11-oxo-10,11-dihydro-5-oxa-4,10-diaza-dibenzo[a,d]cycloheptene-9-carbonitrile 
• 140413-29-2 7,10-Dimethyl-9-nitro-10H-5-oxa-4,10-diaza-dibenzo[a,d]cyclohepten-11-one 
• 140413-33-8 6,9-dimethyl-7-(iminomethoxymethyl)pyrido<2,3-b><1,5>benzoxazepin-5(6H)-one 
• 140413-28-1 7-cyano-6,9-dimethylpyrido<2,3-b><1,5>benzoxazepin-5(6H)-one 
• 140413-35-0 9-Hydroxymethyl-7,10-dimethyl-10H-5-oxa-4,10-diaza-dibenzo[a,d]cyclohepten-11-one 
• 140413-34-9 7-carboxy-6,9-dimethylpyrido<2,3-b><1,5>benzoxazepin-5(6H)-one 
• 140413-32-7 7-carbamoyl-6,9-dimethylpyrido<2,3-b><1,5>benzoxazepin-5(6H)-one 
• 140413-26-9 9-Amino-10-ethyl-7-methyl-10H-5-oxa-4,10-diaza-dibenzo[a,d]cyclohepten-11-one 
• 140413-30-5 7-amino-6,9-dimethylpyrido<2,3-b><1,5>benzoxazepin-5(6H)-one 
• 134894-53-4 7,10-Dimethyl-10H-5-oxa-4,10-diaza-dibenzo[a,d]cyclohepten-11-one 

Relevant academic research and scientific papers

One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source

A facile one-pot protocol for the synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones from commercially available aryl/heteroaryl halides and amino phenols using octacarbonyldicobalt (Co2(CO)8) as an effective metal carbonyl source has been demonstrated. This method proceeds via the sequential coupling of aryl/heteroaryl halides with aminophenol by amidation and intramolecular cyclization to give dibenzoxazepinones/pyridobenzoxazepinones.

Base-regulated tunable synthesis of pyridobenzoxazepinones and pyridobenzoxazines

A base-regulated one-pot protocol for the tunable synthesis of pyridobenzoxazepinones and pyridobenzoxazines has been developed. The preparation of pyridobenzoxazepinones is achieved in moderate to good yield by utilizing an aromatic nucleophilic substitution (SNAr, O-arylation)/carbonylation tandem reaction. Mechanistic studies suggest that SNAr (O-arylation) proceeds prior to the aminocarbonylation. Through the regulation of bases, pyridobenzoxazines can be obtained via successive SNAr (O-arylation and then N-arylation). Base is crucial for the regulation of the products.

Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones

Dibenzoxazepin-11(10H)-ones (III), pyridobenzoxazepin-6(5H)-ones (IV), and pyridobenzoxazepin-5(6H)-ones (V) were found to inhibit human immunodeficiency virus type 1 reverse transcriptase with IC50 values as 19 nM.A-ring substitution has a profound effect on activity, with appropriate substituents at the positions ortho and para to the lactam nitrogen providing dramatically enhanced potency.Substitution in the C-ring is generally neutral or detrimental to activity.Although a C-ring amino substituent at the position meta to the lactam carbonyl is generally beneficial to activity, it has essentially no effect when the A-ring is optimally substituted.Like the dipyridodiazepinone nevirapine, compounds III-V are specific for HIV-1 RT, exhibiting no inhibitory activity against HIV-2 RT or other virial reverse transcriptase enzymes.