14045-45-5Relevant academic research and scientific papers
Bi(OTf)3-Catalyzed Alkyl-Intercepted Meyer-Schuster Rearrangement of Propargylic Alcohols for the Synthesis of 1,2,3,5-Tetrasubstituted Pentane-1,5-diones
Wang, Zhihai,Sun, Yuxing,Zhang, Qinglin,Pan, Wanyong,Li, Tiantian,Yin, Yan
, p. 3329 - 3340 (2022/02/25)
An alkyl intercepted Meyer-Schuster rearrangement reaction with α,β-unsaturated ketones as the electrophiles was first investigated, which provided a facile method to construct 2-methylene-pentane-1,5-diones. Then the in situ generated 2-methylene-pentane-1,5-diones underwent a Michael addition to give diverse 2-malononitrile methyl substituted pentane-1,5-diones in a one-pot fashion. This transformation was reliable on a gram scale. The high yield, convenient experimental operation, and 100% atom economy made it a valuable method for the construction of 1,2,3,5-tetrasubstituted pentane-1,5-dione derivatives.
Preparation method of 2-methene-1, 3, 5-triaryl-1, 5-pentanedione
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Paragraph 0049-0054, (2019/12/02)
The invention relates to a preparation method of 2-methylene-1, 3, 5-triaryl-1, 5-pentanedione, which comprises the following steps: mixing an aromatic ring substituted propargyl alcohol compound, a chalcone derivative, an acid and a solvent, heating, and
