14062-27-2

Basic information

• Product Name: Ethyl (4-methylthiophenyl)acetate
• Synonyms: 4-(methylthio)phenylacetic acid ethyl ester;ethyl (4-methylthiophenyl)acetate;Ethyl (4-methylthiop;Ethyl4-(methylsulphanyl)phenylacetate99%
• CAS NO: 14062-27-2
• Molecular Formula: C₁₁H₁₄O₂S
• Molecular Weight: 210.29
• Mol File: 14062-27-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 30-32°C
• Boiling Point: 302°C
• Flash Point: 136°C
• Appearance: /
• Density: 1.11
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: Ethyl (4-methylthiophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (4-methylthiophenyl)acetate(14062-27-2)
• EPA Substance Registry System: Ethyl (4-methylthiophenyl)acetate(14062-27-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 14062-27-2(Hazardous Substances Data)

Usage

General Description

Ethyl (4-methylthiophenyl)acetate is a chemical compound with the molecular formula C11H14O2S. It is a clear, colorless liquid with a fruity, pineapple-like odor. Ethyl (4-methylthiophenyl)acetate is commonly used as a flavoring and fragrance agent in the food and beverage industry. It is also utilized in the production of perfumes and personal care products. Additionally, ethyl (4-methylthiophenyl)acetate has been found to be an active component in pharmaceuticals and insecticides. This chemical is considered to be relatively safe for use and is not known to pose a significant risk to human health or the environment when handled and used properly.

InChI:InChI=1/C11H14O2S/c1-3-13-11(12)8-9-4-6-10(14-2)7-5-9/h4-7H,3,8H2,1-2H3

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 123-09-1 4-chlorophenyl methyl sulfide 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 62936-31-6 (4-methylsulfanylphenyl)oxoacetic acid ethyl ester 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 5188-07-8 sodium thiomethoxide 
• 104-95-0 (4-bromophenyl)thioanisole 
• 6148-64-7 ethyl potassium malonate 
• 105-53-3 diethyl malonate 
• 100-68-5 methyl-phenyl-thioether 
• 1778-09-2 4-(Methylthio)acetophenone 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 64-17-5 ethanol 
• 221025-49-6 methyl 1-methylsulfinyl-2-(4-methylthiophenyl)vinyl sulfide 

Downstream Products

• 350017-10-6 3-(4-methylsulfanylphenylacetyl)-1-vinyl-pyrrolidin-2-one 
• 1588424-06-9 7-chloro-1-ethyl-3-(4-(methylthio)phenyl)-1,6-naphthyridin-2(1H)-one 
• 1035261-66-5 diethyl 2-(2-methyl-2-(4-(methylthio)phenyl)propanoyloxy)malonate 
• 1040860-73-8 2-methyl-2-(4-(methylthio)phenyl)propanoic acid chloride 
• 80854-31-5 2-methyl-2-(4-(methylthio)phenyl)propanoic acid 
• 1263796-97-9 3-(4-methylthiobenzyl)-1,2,4-triazole-5-thiol 
• 1313870-47-1 4-methylthiophenylacetyl thiosemicarbazide 
• 1287721-85-0 2-(4-methylthiobenzyl)-6-(3,5-difluoro-benzylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one 
• 1287721-84-9 C₁₉H₁₅N₃O₂S₂ 
• 1287721-83-8 C₂₁H₁₈N₄O₅S₂ 
• 1287721-82-7 2-(4-methylthiobenzyl)-6-(3,4-dimethoxy-benzylidene)-thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one 
• 1287721-81-6 C₂₃H₁₅Cl₂N₃O₂S₂ 
• 1287721-80-5 C₂₃H₁₅ClN₄O₄S₂ 
• 1287721-79-2 C₂₄H₁₈N₄O₄S₂ 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Chlorotrimethylsilane and Sodium Iodide: A Useful Combination for the Regioselective Deoxygenation of Arylalkyl-α-Diketones

An efficient regioselective deoxygenation of arylalkyl-1,2-diketones by the couple trimethylsilylchloride/sodium iodide has been reported. In all cases, the deoxygenation takes place on the carbonyl group (Cα=O) proximal to the aromatic ring in methylene chloride at room temperature in good yields, furnishing a series of variously functionalized alkylbenzylketones. A large range of functional groups were well tolerated on the ortho-, meta- and para-positions by this mild process regardless of their electronic effects, demonstrating the general character of the present methodology. The trimethylsilylchloride/sodium iodide reducing process was also successfully applied to reduce α-ketoacid and α-ketoester substrates. (Figure presented.).

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