140640-41-1

Upstream product

• 6484-25-9 4-chloro-2-phenylquinazoline 
• 100-52-7 benzaldehyde 
• 108-88-3 toluene 
• 62-53-3 aniline 
• 100-47-0 benzonitrile 
• 536-74-3 phenylacetylene 
• 1527-91-9 N-phenylbenzamidine 
• 13141-38-3 2-phenylethynylaniline 
• 1373169-43-7 N-(2-(phenylethynyl)phenyl)benzimidamide 

Relevant academic research and scientific papers

Photoredox synthesis of functionalized quinazolinesviacopper-catalyzed aerobic oxidative Csp2-H annulation of amidines with terminal alkynes

We have developed a visible light-induced photo-redox copper-catalyzed oxidative Csp2-H annulation (Friedel-Crafts-type cyclization) of amidines with terminal alkynes at room temperature to synthesize functionalized quinazolines. We report copp

Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes

A novel copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes with 2-aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields. A key intermediate was detected and the kinetics isotope effect (KIE) indicated that C-H bond cleavage was the rate-determining step.

Copper-catalyzed oxidative diamination of terminal alkynes by amidines: Synthesis of 1,2,4-trisubstituted imidazoles

An efficient copper-catalyzed synthesis of 1,2,4-trisubstituted imidazoles using amidines and terminal alkynes has been developed. Overall, the oxidative process, which involves Na2CO3, pyridine, a catalytic amount of CuCl2/sub

Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles

A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidine

Catalytic action of azolium salts. IV. Preparations of 4-aroylquinazolines and 4-aroyl-1H-pyrazolo[3,4-d]pyrimidines by catalytic action of 1,3-dimethylimidazolium iodide

The ability of 1,3-dimethylimidazolium iodide (1) to catalyze the aroylation of the chloroheteroarenes 4-8 with arenecarbaldehydes 3 as sources of the aroyl groups was examined in order to develop a preparative method of aroylheteroarenes. In the presence

Catalytic action of azolium salts. II. Aroylation of 4-chloroquinazolines with aromatic aldehydes catalyzed by 1,3-dimethylbenzimidazolium iodide

When a mixture of 4-chloroquinazoline (7), an aromatic aldehyde 6, sodium hydride, and a catalytic amount of 1,3-dimethylbenzimidazolium iodide (1) in tetrahydrofuran (THF) was refluxed with stirring for an appropriate time, the chlorine atom of 7 was rep